Assoc Prof Tracy Melzer

PhD

Imaging Research Manager

New Zealand Brain Research Institute, Christchurch

Associate Professor

Department of Medicine, University of Otago, Christchurch

Phone: (+64 3) 595 6869

Current Role

As MRI Research Manager, I oversee all imaging at the NZBRI. This provides me with the opportunity to become involved in a wide range of neurological research, ranging from child development to neurodegenerative diseases, and more. 

 

As an Associate Professor in the Department of Medicine, my primary focus is on the development and application of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) techniques to advance our understanding of cognitive decline in Parkinson’s disease.

Research Interests

  • MRI (structural, diffusion, perfusion, functional)
  • Metabolic and amyloid PET imaging (positron emission tomography)
  • Parkinson’s disease
  • Cognitive impairment

Education

  • PhD in Medicine, University of Otago, NZ
  • BSc (Hons) in Medical Physics, University of Canterbury, NZ
  • BA (Hons) in Physics, University of Montana, USA

Interests

  • Spending time with my wife and two daughters
  • Fishing
  • Running
  • Tramping
  • Cycling

Projects

  • Tracking Parkinson’s disease progression over the long term
  • Cerebrovascular health in Parkinson’s disease

Link to Associate Professor Tracy Melzer's Google Scholar page

Publications

Provided on request for non-commercial personal use by researchers.

2024

Download Diagnosis of Delayed Post-Hypoxic Leukoencephalopathy (Grinker’s Myelinopathy) with MRI Using Divided Subtracted Inversion Recovery (dSIR) Sequences: Time for Reappraisal of the Syndrome?
Newburn, G., Condron, P., Kwon, E. E., McGeown, J. P., Melzer, T. R., Bydder, M., ..., .., Bydder, G. M. (2024). Diagnosis of Delayed Post-Hypoxic Leukoencephalopathy (Grinker’s Myelinopathy) with MRI Using Divided Subtracted Inversion Recovery (dSIR) Sequences: Time for Reappraisal of the Syndrome? Diagnostics, 14(4), 418. 2075-4418/14/4/418
Download Dementia dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses.
Reuben, A, Richmond-Rakerd, LS, Milne, B., ..., Keenan, R., ..., Melzer, T., ..., Moffitt, T.E. (2024). Dementia dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses. Alzheimer's Dementia, 1-12. 10.1002/alz.13727

2023

Download Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?
Barrett-Young, A., Abraham, W. C., Cheung, C. Y., Gale, J., Hogan, S., Ireland, D., ... , Melzer, T. , ... , Poulton, R. (2023). Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain? Eye and Brain, 25-35. 10.2147/EB.S402510
Dalrymple-Alford, J.C., Anderson, T.J., Melzer, T.R. (2023). Thalamus, thalamocortical networks, and non-motor symptoms in Parkinson’s disease. book chapter in Cerebral Cortex and Thalamus XII.
Download Acquired Stuttering in Parkinson's Disease.
Gooch, E. A., Horne, K.-L., Melzer, T. R., McAuliffe, M. J., MacAskill, M., Dalrymple‐Alford, J. C., Anderson, T.J., Theys, C. (2023). Acquired Stuttering in Parkinson's Disease. Movement Disorders Clinical Practice. 10.1002/mdc3.13758
Download Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium.
Kennedy, E., Vadlamani, S., Lindsey, H. M., Lei, P. W., Pugh, M. J., Adamson, M., ... , Anderson, T.J., ... , Dalrymple-Alford, J.C., ... , Melzer, T.R, ... , Myall, D.J., ... , Wilde, E. A. (2023). Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium. bioRxiv, 2023-01. 10.1101/2023.01.16.524331
Download Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.
Kerestes, R., Laansma, M., ..., Anderson, T., ..., Dalrymple-Alford, J., ..., Melzer, T., ..., Pitcher, T., ..., the ENIGMA-Parkinson's Study (2023). Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study. Movement Disorders. 10.1002/mds.29611
Download The New Zealand Parkinson’s Progression Programme.
MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Myall, D. J., Horne, K.-L., Shoorangiz, R., Almuqbel, M. M., Livingston, L., Grenfell, S., Pascoe, M. J., Marshall, E. T., Marsh, S., Perry, S. E., Meissner, W. G., Theys, C., Le Heron, C. J., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J. (2023). The New Zealand Parkinson’s Progression Programme. Journal of the Royal Society of New Zealand, 53, 466-488. 10.1080/03036758.2022.2111448
Download Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease.
Morris, L. A., Harrison, S. J., Melzer, T. R., Dalrymple-Alford, J. C., Anderson, T. J., MacAskill, M. R., Le Heron, C. J. (2023). Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease. Brain, awad113. 10.1093/brain/awad113
Download Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis.
Murray, S.J., Almuqbel, M.M., Felton, S.A., Palmer, N.J., Myall, D.J., Shoorangiz, R., Ella, A., Keller, M., Palmer, D.N., Melzer, T.R. and Mitchell, N.L. (2023). Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis. Brain Communications, 5(1). 10.1093/braincomms/fcac339
Download Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities.
Whitman, E. T., Knodt, A. R., Elliott, M. L., Abraham, W. C., Cheyne, K., Hogan, S., Ireland, D., Keenan, R., Leung, J. H., Melzer, T. R., Poulton, R., Purdy, S. C., Ramrakha, S., Thorne, P. R., Caspi, A., Moffitt, T. E., Hariri, A. R. (2023). Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities. Cerebral Cortex. 10.1093/cercor/bhad109

2022

Download Reproducibility and repeatability of magnetic resonance imaging in dementia.
Morgan, C.A., Roberts, R.P., Chaffey, T., Tahara-Eckl, L., van der Meer, M., Günther, M., Anderson, T.J., Cutfield, N.J., Dalrymple-Alford, J.C., Kirk, I.J., Addis, D R., Tippett, L.J., Melzer, T.R. (2022). Reproducibility and repeatability of magnetic resonance imaging in dementia. Physica Medica, 101, 8-17. doi.org/10.1016/j.ejmp.2022.06.012
Download Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: the MagNUM Study.
Poppe, T., Thompson, B., Boardman, J. P., Bastin, M. E., Alsweiler, J., Deib, G., Harding, J. E., Crowther, C. A., the MagNUM Study Group (2022). Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: the MagNUM Study. eBioMedicine, 103923 . 10.1016/j.ebiom.2022.103923
Download Dementia Prevention Research Clinic: A longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa.
Tippett, L. J., Cawston, E. E., Morgan, C. A., Melzer, T. R., Brickell, K. L., Ilse, C., Cheung, G., Kirk, I. J., Roberts, R. P., Govender, J., Griner, L., Le Heron, C., Buchanan, S., Port, W., Dudley, M., Anderson, T. J., Williams, J. M., Cutfield, N. J., Dalrymple-Alford, J. C., … the NZ-DPRC. (2022). Dementia Prevention Research Clinic: A longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa. Journal of the Royal Society of New Zealand. 10.1080/03036758.2022.2098780
Zhao, Y., Laansma, M. A., van Heese, E. M., Owens-Walton, C., Parkes, L. M., Debove, I., Rummel, C., Wiest, R., Cendes, F., Guimaraes, R., Yasuda, C. L., Wang, J.-J., Anderson, T. J., Dalrymple-Alford, J. C., Melzer, T. R., Pitcher, T. L., Schmidt, R., Schwingenschuh, P., Garraux, G., … for the ENIGMA consortium. (2022). Learning interpretable regularized ordinal models from 3D mesh data for neurodegenerative disease staging. In Abdulkadir, Bathula, Dvornek, Habes, Kia, Kumar, & Wolfers (Eds.),. Machine Learning in Clinical Neuroimaging, 13596, 115–124. 10.1007/978-3-031-17899-3_12

2021

Download Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease.
Basukala, D., Mukundan, R., Lim, A., Hurrell, M. A., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J., Myall, D. J., Melzer, T. R. (2021). Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease. Computers & Electrical Engineering, 91, 107091. 10.1016/j.compeleceng.2021.107091
Download Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.
Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Langevin, S., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2021). Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and Psychopathology, 1–11. 10.1017/S0954579421000377
Download Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Elliott, M. L., Caspi, A., Houts, R. M., Ambler, A., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R., Knodt, A., Leung, J. H., Melzer, T. R., Purdy, S. C., Ramrakha, S., Richmond-Rakerd, L. S., Righarts, A., Sugden, K., Thomson, W. M., Thorne, P. R., Williams, B. S., Wilson, G., Hariri, A. R., Poulton, R.,  Moffitt, T. E. (2021). Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy. Nature Aging, 1, 295-308. 10.1038/s43587-021-00044-4
Download Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.
Elliott, M.L., Belsky, D.W., Knodt, A.R., Ireland, D., Melzer, T.R., Poulton, R., Ramrakha, S., Caspi, A., Moffitt, T.E. and Hariri, A.R. (2021). Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort. Molecular Psychiatry, 26, 3829–3838. 10.1038/s41380-019-0626-7
Download Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it.
Horne, K., MacAskill, M. R., Myall, D. J., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple‐Alford, J. C. (2021). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. Movement Disorders Clinical Practice, 8, 390-399. 10.1002/mdc3.13151
Download International multicenter analysis of brain structure across clinical stages of Parkinson’s disease.
Laansma, M. A., Bright, J. K., Al‐Bachari, S., Anderson, T. J., Ard, T., Assogna, F., Baquero, K. A., Berendse, H. W., Blair, J., Cendes, F., Dalrymple‐Alford, J. C., Bie, R. M. A., Debove, I., Dirkx, M. F., Druzgal, J., Emsley, H. C. A., Garraux, G., Guimarães, R. P., Gutman, B. A., Helmich, R. C., Klein, J. C., Mackay, C. E., McMillan, C. T., Melzer, T. R., Parkes, L. M., Piras, F., Pitcher, T. L., Poston, K. L., Rango, M., Ribeiro, L. F., Rocha, C. S., Rummel, C., Santos, L. S. R., Schmidt, R., Schwingenschuh, P., Spalletta, G., Squarcina, L., Heuvel, O. A., Vriend, C., Wang, J., Weintraub, D., Wiest, R., Yasuda, C. L., Jahanshad, N., Thompson, P. M., Werf, Y. D., The ENIGMA‐Parkinson’s Study. (2021). International multicenter analysis of brain structure across clinical stages of Parkinson’s disease. Movement Disorders , 36, 2583-2594. 10.1002/mds.28706
Download Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia.
Morgan, C. A., Melzer, T. R., Roberts, R. P., Wiebels, K., Mutsaerts, H. J. M. M., Spriggs, M. J., Dalrymple-Alford, J. C., Anderson, T. J., Cutfield, N. J., Deib, G., Pfeuffer, J., Addis, D. R., Kirk, I. J., Tippett, L. J. (2021). Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia. Scientific Reports, 11(1), 23325. 10.1038/s41598-021-02313-z
Download Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease.
Murray, S. J., Russell, K. N., Melzer, T. R., Gray, S. J., Heap, S. J., Palmer, D. N., Mitchell, N. L. (2021). Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease. Experimental Eye Research, 207, 108600. 10.1016/j.exer.2021.108600
Download Childhood self-control forecasts the pace of midlife aging and preparedness for old age.
Richmond-Rakerd, L. S., Caspi, A., Ambler, A., d’Arbeloff, T., de Bruine, M., Elliott, M., Harrington, H., Hogan, S., Houts, R. M., Ireland, D., Keenan, R., Knodt, A. R., Melzer, T. R., Park, S., Poulton, R., Ramrakha, S., Rasmussen, L. J. H., Sack, E., Schmidt, A. T., … Moffitt, T. E. (2021). Childhood self-control forecasts the pace of midlife aging and preparedness for old age. Proceedings of the National Academy of Sciences, 118, e2010211118. 10.1073/pnas.2010211118
Download Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology.
Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., Moffitt, T. E., Caspi, A., Hariri, A. R. (2021). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry, 178. 10.1176/appi.ajp.2020.19090934
Download Midlife cardiovascular fitness is reflected in the brain’s white matter.
d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., Ramrakha, S., Poulton, R., Caspi, A., Moffitt, T. E., Hariri, A. R. (2021). Midlife cardiovascular fitness is reflected in the brain’s white matter. Frontiers in Aging Neuroscience, 13, 652575. 10.3389/fnagi.2021.652575

2020

Download Compressed sensing in metal hip imaging: our experience.
Almuqbel, M., Melzer, T. R., Oram, B. J., Keenan, R. J. (2020). Compressed sensing in metal hip imaging: our experience. MAGNETOM Flash, 77, 4-8.
Download Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: results of a randomised placebo-controlled trial.
Borlase, N., Melzer, T. R., Eggleston, M. J., Darling, K. A., Rucklidge, J. J. (2020). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: results of a randomised placebo-controlled trial. Nutritional Neuroscience , 23, 876-886. 10.1080/1028415X.2019.1574329
Download Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease.
Borlase, N., Myall, D., Melzer, T., Livingston, L., Watts, R., Keenan, R., MacAskill, M., Anderson, T., Dalrymple-Alford, J. (2020). Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease. bioRxiv, 2020.05.21.1096. 10.1101/2020.05.21.109660
Download Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort.
Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2020). Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort. The Lancet Psychiatry, S22150366203000. 10.1016/S2215-0366(20)30002-X
Darlow, B. A., Woodward, L. J., Levin, K. J., Melzer, T., Horwood, L. J. (2020). Perinatal and childhood predictors of general cognitive outcome at 28 years in a very‐low‐birthweight national cohort. Developmental Medicine & Child Neurology, 62(12), 1423-1428. 10.1111/dmcn.14649
Grasby, K. L. & Jahanshad, N. et al. (2020). The genetic architecture of the human cerebral cortex. Science, 367(6484), eaay6690. 10.1126/science.aay6690
Download Test-retest reliability and sample size estimates after MRI scanner relocation.
Melzer, T.R., Keenan, R.J., Leeper, G.J., Kingston-Smith, S., Felton, S.A., Green, S.K., Henderson, K.J., Palmer, N.J., Shoorangiz, R., Almuqbel, M.M., Myall, D.J. (2020). Test-retest reliability and sample size estimates after MRI scanner relocation. Neuroimage 211, 116608. 10.1016/j.neuroimage.2020.116608
Download Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease.
Myall, D.J., Horne, K., MacAskill, M.R., Livingston, L., Pitcher, T.L., Melzer, T.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2020). Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease. bioRxiv, 2020.05.31.1268. 10.1101/2020.05.31.126870
Download Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology.
Romer, A.L., Elliott, M.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E., Caspi, A., Hariri, A.R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry. 10.1176/appi.ajp.2020.19090934
Download Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study.
Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study. Disability and Rehabilitation, 42, 1942-1953. 10.1080/09638288.2018.1542461
Download Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers.
Theys, C., Kovacs, S., Peeters, R., Melzer, T. R., van Wieringen, A., De Nil, L. F. (2020). Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers. PLOS One, 15(1), e0228452. 10.1371/journal.pone.0228452
Wheelock, M. D., Lean, R. E., Bora, S., Melzer, T. R., Eggebrecht, A. T., Smyser, C. D., Woodward, L. J. (2020). Functional connectivity network disruption underlies domain-specific attention impairments in attention for children born very preterm. Cerebral Cortex. 10.1093/cercor/bhaa303
Download White matter hyperintensities are common in midlife and already associated with cognitive decline.
d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T.J., Caspi, A., Moffitt, T. E., Hariri, A. R. (2020). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Communications, 1(1), fcz041. 10.1093/braincomms/fcz041

2019

Download Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: a preliminary functional magnetic resonance imaging study.
Douglas, K. M., Groves, S., Porter, R. J., Jordan, J., Wilson, L., Melzer, T. R., Wise, R. G., Bisson J. I., Bell, C. J. (2019). Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: a preliminary functional magnetic resonance imaging study. Australian & New Zealand Journal of Psychiatry, 53, 1167–1178. 10.1177/0004867419851860
Ella, A., Barrière, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9, 44–51. 10.1093/af/vfz024
Download General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks.
Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516–532. 0.1016/j.neuroimage.2019.01.068
Download Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease.
Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K., Young, B., Pascoe, M., Almuqbel, M. A., Wang, J., Marsh, S., Miller, D. H., Dalrymple-Alford, J. C., Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease. Frontiers in Neurology, 10, 391. 10.3389/fneur.2019.00391
Download Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults.
Pascoe, M.J., Melzer, T.R., Horwood, L.J., Woodward, L.J., Darlow, B.A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical, 22, 101780. 10.1016/j.nicl.2019.101780
Download Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.
Romer, A.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E. and Caspi, A. (2019). Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Molecular Psychiatry, 1-8. 10.1038/s41380-019-0621-z

2018

Download  MRI artefact in the rectum caused by ingested orthodontic brackets.
Almuqbel, M. M,  Leeper, G. J.,  Petelo, J. F., Page, T. J.,  Melzer, T. R. (2018).  MRI artefact in the rectum caused by ingested orthodontic brackets. Radiography, 24, e48-e50. 10.1016/j.radi.2017.10.002
Download Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI.
Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R., Melzer, T. R. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91:20170593, 1-5. 10.1259/bjr.20170593
Download Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis.
Castellazzi, G., Debernard, L., Melzer, T. R., Dalrymple-Alford, J. C., D’Angelo, E., Miller, D. H., Wheeler-Kingshott, C. A., Mason, D. F. (2018). Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis. Frontiers in Neurology, 9, 690. 10.3389/fneur.2018.00690
Download The genetic architecture of the human cerebral cortex.
Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., ..., Melzer, Tracy R., ..., Pitcher, Toni L., ..., Anderson, Tim J., ..., Dalrymple-Alford, John C., ..., on behalf of the Enhancing NeuroImaging Genetics through Meta-Analysis Consortium - Genetics working group (2018). The genetic architecture of the human cerebral cortex. BioRxiv, 399402. 10.1101/399402
Download Brain activation during processing of genuine facial emotion in depression: Preliminary findings.
Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., Johnston, L.C., Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders, 225, 91-96. 10.1016/j.jad.2017.07.049
Download Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease.
Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., Gray, S. J., Hughes, S. M., Palmer, D. N. (2018). Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26, 2366-2378. 10.1016/j.ymthe.2018.07.015
Download Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses.
Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., Barrell, G. K., Palmer, D.N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain and Behavior, 8, e01096. 10.1002/brb3.1096
Download Untangling chronic pain and post-concussion symptoms: the significance of depression.
Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Hooper, G. J., Anderson, T. J. (2018). Untangling chronic pain and post-concussion symptoms: the significance of depression. Brain Injury, 32, 583-592. 10.1080/02699052.2018.1432894

2017

Download Attention and regional gray matter development in very preterm children at age 12 years.
Lean, R. E., Melzer, T. R., Bora, S., Watts, R., Woodward, L. J. (2017). Attention and regional gray matter development in very preterm children at age 12 years. Journal of the International Neuropsychological Society, 23, 539-550. 10.1017/S1355617717000388

2016

Download Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Almuqbel, M., Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Wood, K., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. 10.1016/j.parkreldis.2015.11.008
Download Different PD-MCI criteria and risk of dementia in Parkinson’s disease: Four year longitudinal study.
Wood, K., Myall, D.J., Livingston, L., Melzer, T.R., Pitcher, T.L., MacAskill, M.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson’s disease: Four year longitudinal study. npj Parkinson's Disease, 2, 15027. 10.1038/npjparkd.2015.27

2015

Download The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead.
Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead. BMC Pediatrics, 15, 90. 10.1186/s12887-015-0413-9
Download Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis.
Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging. 10.1016/j.pscychresns.2015.10.00
Download Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness.
Innes, CRH, Kelly, PT, Hlavac, M, Melzer, TR, Jones, RD (2015). Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep, 38, 699-706. 10.5665/sleep.4658
Download Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease.
Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Watts, R., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLOS ONE, 10, e0143923. 10.1371/journal.pone.0143923

2014

Download Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis.
Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A., Dalrymple-Alford, J. C., Miller, D. H. , Mason, D.F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 85. 10.1136/jnnp-2013-305612
Download Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.
Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C. , Anderson, T.J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.  Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. 10.1038/jcbfm.2014.40

2013

Download Cross-Sectional Area of the Anterior Belly of the Digastric Muscle: Comparison of MRI and Ultrasound Measures.
Macrae, P., Jones, R., Myall, D., Melzer, T. , Huckabee, M. (2013). Cross-Sectional Area of the Anterior Belly of the Digastric Muscle: Comparison of MRI and Ultrasound Measures. Dysphagia, 28, 375-380. 10.1007/s00455-012-9443-8
Download The evolution of diffusion tensor imaging in Parkinson’s disease research.
Melzer, T. (2013). The evolution of diffusion tensor imaging in Parkinson’s disease research. Movement Disorders, 28, 1316. 10.1002/mds.25566
Download White matter microstructure deteriorates across cognitive stages in Parkinson disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80, 1841-1849. 10.1212/WNL.0b013e3182929f62

2012

Download Grey matter atrophy in cognitively impaired Parkinson’s disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 83(2), 188-194. 10.1186/2047-9158-1-17
Download Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study.
Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. 10.1186/2047-9158-1-17

2011

Download Characterizing mild cognitive impairment in Parkinson’s disease.
Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R., Watts, R., Anderson, T. J. (2011). Characterizing mild cognitive impairment in Parkinson’s disease. Movement Disorders, 26(4), 629-636. 10.1002/mds.23592
Download Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders.
Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., Jones, R.D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders.  Quarterly Journal of Experimental Psychology,  64, 1714-1725.
Download Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., Shankaranarayanan, A., Alsop, D. C., Dalrymple-Alford, J. C., Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease. Brain,  134(3), 845-855. 10.1093/brain/awq377

2010

Download The MoCA: Well-suited screen for cognitive impairment in Parkinson’s disease.
Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., Anderson, T.J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson’s disease. Neurology, 75, 1717-1725. 10.1212/WNL.0b013e3181fc29c9

2008

Download Bio-medical X-ray imaging with spectroscopic pixel detectors.
Butler, A., Anderson, N., Tipples, R., Cook, N., Watts, R., Meyer, J., Bell, A., Melzer, T., Butler, P. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors.  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment,  591, 141-146. 10.1016/j.nima.2008.03.039
Download Spectroscopic biomedical imaging with the Medipix2 detector.
Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., Butler, P.H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Science in Medicine, 31(4), 300-306.

Abstracts and Short papers

2022

Download TV‐L1 Ordinal Logistic Regression Reveals New Morphometric Patterns Related to Parkinsonian Symptom Severity: An ENIGMA‐PD study.
Zhao, Y., van Heese, E., Laansma, M. A., Al‐Bachari, S., Anderson, T., Assogna, F., ..., Dalrymple-Alford, J., ..., Melzer, T., ..., Pitcher, T., ..., Gutman, B. A. (2022). TV‐L1 Ordinal Logistic Regression Reveals New Morphometric Patterns Related to Parkinsonian Symptom Severity: An ENIGMA‐PD study. Alzheimer's & Dementia, 18, e067037. 10.1002/alz.067037

2020

Download Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it.
Horne, K.-L., MacAskill, M. R., Myall, D., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple-Alford, J. C. (2020). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. MedRxiv, 2020, 09, 01, 20186312. https://doi.org/10.1101/2020.09.01.20186312

2019

Download Automated segmentation of substantia nigra and red nucleus in quantitative susceptibility mapping images.
Basukala, D., Mukundan, R., Melzer, T., Lim, A. (2019). Automated segmentation of substantia nigra and red nucleus in quantitative susceptibility mapping images. In 2019 20th International Conference on Parallel and Distributed Computing, Applications an.
d'Arbeloff, T., Elliott, M., Knodt, A., Melzer, T., Keenan, R., Ireland, D., … & Hariri, A. (2019). White matter lesions are common in midlife and associated with cognitive decline. Biological Psychiatry, 85(10), S213. 10.1016/j.biopsych.2019.03.539

2018

Download Segmentation of substantia nigra using weighted thresholding method, In 2018 International Conference on Image and Vision Computing New Zealand (IVCNZ) (pp.
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra using weighted thresholding method, In 2018 International Conference on Image and Vision Computing New Zealand (IVCNZ) (pp. 1-6).
Download Segmentation of substantia nigra for the automated characterization of Parkinson’s disease.
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra for the automated characterization of Parkinson’s disease. In 2018 IEEE International Conference on Image Processing, Applications an.

2016

Horne, K, Myall, DJ, Livingston, L, Grenfell, SF, Melzer, TR, Pitcher, TL, MacAskill, MR, Anderson, TJ, Dalrymple-Alford, JC (2016). Risk of dementia in Parkinson’s disease: Towards optimal short cognitive testing.  Proceedings of the 34th International Winter Conference on Brain Research, 1.
Melzer, TR, Keenan, RJ, Myall, DJ, Kaur, G, Livingston, L, Horne, K, Marsh, S, MacAskill, MR, Dalrymple-Alford, JC, Anderson, TJ (2016). Amyloid imaging and cognition in Parkinson’s disease: Interim report.  Proceedings of the 34th International Winter Conference on Brain Research, 3.

2015

Almuqbel, M, Melzer, TR, Myall, DJ, MacAskill, MR, Livingston, L, Pitcher, TL, Dalrymple-Alford, JC, Anderson, TJ (2015). Longitudinal magnetic resonance spectroscopy in Parkinson’s disease. Proceedings of the 21st Annual Meeting of the Organization for Human Brain Mapping.
Melzer, TR, Myall, DJ, MacAskill, MR, Livingston, L, Pitcher, TL, Watts, R, Keenan, RJ, Dalrymple-Alford, JC, Anderson, TJ (2015). White matter lesions contribute to future dementia in Parkinson’s disease. Proceedings of the 21st Annual Meeting of the Organization for Human Brain Mapping.

2014

Almuqbel, M., Melzer, T., Myall, D., MacAskill, M., Livingston, L., Wood, K., Pitcher, T., Dalrymple-Alford, J. , Anderson, T. (2014). Cognitive status in Parkinsons disease characterised by magnetic resonance spectroscopy.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,  32, 34.
Melzer, T., Myall, D., Livingston L., , Wood, K., Pitcher, T., Keenan, R., MacAskill, M., Dalrymple-Alford, J. , Anderson, T. (2014). White matter lesions - a factor in developing dementia in patients with Parkinsons disease.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand, 32, Abstract 3.5.
Myall, D., Wood, K., Livingston, L., Pitcher, T., Melzer, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Individualised medicine: Predicting dementia in Parkinsons disease.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,  32, Abstract 8.1.
Wood, K., Myall, D., Livingston, L., Melzer, T., Pitcher, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Comparing mild cognitive impairment criteria in Parkinsons disease: influence on dementia onset.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand, 32, Abstract 6.4.

2013

Dalrymple-Alford, J. C., Livingston, L., Melzer, T. R., Wood, K., Goh, T. J., Pitcher, T. L., Graham, C. F., Keenan, R. J., MacAskill, M. R. , Anderson, T.J. (2013). Current perspectives on Parkinsons disease: Cognition to the fore.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,  Volume 31, Abstract 29.
Dalrymple-Alford, J., McCurrie, C., Anderson, T., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R. , Melzer, T. (2013). Domain specific cognitive dysfunction in Parkinson’s Disease and associated pattern of grey matter atrophy.  Proceedings of the Movement Disorders Society 17th International Congress - Sydney, Abstract 572..
Debernard, L., Alla, S., Melzer, T., Van Stockum, S., Graham, C., Dalrymple-Alford, J., Miller, DH, Mason, D (2013). Cortical perfusion is associated with cognitive function in relapsing remitting multiple sclerosis patients (Abstract).  Multiple Sclerosis,  19(S11), 171. 10.1177/1352458513502429
Grenfell, S., Melzer, T. R., Young, B., Wang, A, Livingston, L., Keenan, R. J., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Reduced default mode network connectivity and autobiographical memory in mild cognitive impairment.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown, Volume 31, Abstract 27.
Melzer, T. R., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R., Dalrymple-Alford, J. , Anderson, T. (2013). Serial DTI and cognitive decline in Parkinsons disease. Proceedings of the Movement Disorders Society 17th International Congress, Sydney,  Movement Disorders, 28 Supplement 1, 555.
Wood, K., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Criteria for Parkinson’s disease with mild cognitive impairment associated with increased progression to dementia.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,  Volume 31, 58.