Dr Kyla-Louise Horne

PhD, BA (Hons), BSc

Research Fellow

New Zealand Brain Research Institute, Christchurch

Phone: 03 928 1497

Background


I hold a PhD in Neuropsychology from the University of Canterbury with clinical experience in Parkinson's, Alzheimer's and Huntington's disease. I am actively involved in both local and national health research networks, including the Health Research Society of Canterbury and the Aotearoa Brain Project. Currently I am the Editor and Programme Co-ordinator of the Australasia Winter Conference on Brain Research.

 

My research expertise is in the development and progression of cognitive and neuropsychiatric symptoms that may occur in neurodegenerative conditions, such as Parkinson’s, Huntington’s and Alzheimer’s disease, and future dementia risk. I have experience using advanced quantitative brain imaging analysis, machine learning and advanced statistical modelling to better understand neurodegenerative processes in the ageing brain. I also have been working with Prof Simon Lewis at the University of Sydney to examine hallucinations in Parkinson’s disease to see if they could be an early clinical biomarker or increased dementia risk. Recently, I have begun working with Dr Campbell Le Heron to investigate Apathy in Huntington’s disease.

 

In addition to my research, I work part-time within Prof. Tim Anderson's NZBRI Clinical Trials Research team. We have a number of clinical trials currently underway that cover a broad range of neurological conditions, including Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, Multi-System Atrophy and Motor Neuron Disease. 

 


Current Research

 

I am currently investigating Apathy and other mood disorders in Huntington's and Parkinson's disease, as well developing a new area of research within the NZBRI to examine hallucinations in Parkinson’s disease.

 

 

Research Interests

  • Parkinson's disease
  • Huntington's disease
  • Alzheimer's disease
  • Ageing
  • Cognitive Impairment
  • Dementia
  • Hallucinations
  • Perceptual disturbances
  • Mood disorders
  • Caregiver Burden
     

Interests

 

In my spare time I enjoy gardening, cooking, playing with my munchkin cats and spending time with family and friends.

 

 

Projects

  • New Zealand Parkinson's Progression Programme (NZP3)
  • Cognitive and Neuropsychiatric symptoms in Parkinson's disease
  • Dementia risk in Parkinson's disease
  • Hallucinations in Parkinson's disease
  • MRI-derived modelling of ageing in Parkinson's disease
  • Speech disfluencies in Parkinson's disease
  • Apathy and other mood disorders in Huntington's disease 

 

Supervisory roles


2021-2024 - Ann Holden, University of Otago, Christchurch PhD. Project Title: "Investigation of Visual Hallucinations in Parkinson’s Disease".

2020 - Eloise Gooch, University of Canterbury CMDS490 Honors Project. Project Title: "Disentangling the contribution of motor and cognitive factors to the occurrence of speech disfluencies in Parkinson’s disease".

2019/2020 - Two master of Data Science summer students, University of Canterbury 10-week project at the NZBRI. Project title: "Hallucinations in Parkinson’s disease: Do patients and their significant others report the same symptoms?"


 

Link to Dr Kyla-Louise Horne's Google Scholar page

 

Note: Prior to May 2016, I published under my maiden name of 'Wood'.

 

 

Publications

Provided on request for non-commercial personal use by researchers.

2024

Download Early‐phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease.
Aye, W. W., Stark, M. R., Horne, K.-L., Livingston, L., Grenfell, S., Myall, D. J., Pitcher, T.L., Almuqbel, M.M., Keenan, R. J., Meissner, W.G., Dalrymple-Alford, J., Anderson, T.J., Le Heron, C., Melzer, T. R. (2024). Early‐phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(2), e12601.. 10.1002/dad2.12601
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Download Higher Frequency of Stuttered Disfluencies Negatively Affects Communicative Participation in Parkinson's Disease.
Gooch, E., Melzer, T.R., Horne, K.L., Grenfell, S., Livingston, L., Pitcher, T., Dalrymple-Alford, J.C., Anderson, T.J., McAuliffe, M.J., Theys, C. (2024). Higher Frequency of Stuttered Disfluencies Negatively Affects Communicative Participation in Parkinson's Disease. Journal of Speech Language and Hearing Research, 1-12. 10.1044/2024_JSLHR-24-00018
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Download Cross-Sectional and Longitudinal Association of Clinical and Neurocognitive Factors With Apathy in Patients With Parkinson Disease.
Le Heron, C., Horne, K. L., MacAskill, M. R., Livingston, L., Melzer, T. R., Myall, D., Pitcher, T., Dalrymple-Alford, J., Anderson, T., Harrison, S. (2024). Cross-Sectional and Longitudinal Association of Clinical and Neurocognitive Factors With Apathy in Patients With Parkinson Disease. Neurology, 102(12), e209301. 10.1212/WNL.0000000000209301
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Download Decision cost hypersensitivity underlies Huntington’s disease apathy.
Morris, L. A., Horne, K. L., Manohar, S., Paermentier, L., Buchanan, C., MacAskill, M., Myall, D., Apps, M., Roxburgh, R., Anderson, T., Husain, M., Le Heron, C. (2024). Decision cost hypersensitivity underlies Huntington’s disease apathy. Brain, awae296. 10.1093/brain/awae296
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Download Apathy and Impulsivity Co-Occur in Huntington's Disease.
Morris, L.-A., Horne, K.-L., Paermentier, L., Buchanan, C.M., MacAskill, M., Myall, D., Husain, M., Roxburgh, R., Anderson, T. and Heron, C.L. (2024). Apathy and Impulsivity Co-Occur in Huntington's Disease. Brain and Behavior, 14: e70061.. 10.1002/brb3.70061
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Download Disrupted Time Perception Underlies Motivational Disturbances in Huntington’s Disease.
Morris, L.A., Horne, K.L., Manohar, S., Paermentier, L., Buchanan, C.M., MacAskill, M., Myall, D., Roxburgh, R., Anderson, T. and Le Heron, C. (2024). Disrupted Time Perception Underlies Motivational Disturbances in Huntington’s Disease. Timing & Time Perception, 1(aop), 1-24. 10.1163/22134468-bja10115
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2023

Download Acquired Stuttering in Parkinson's Disease.
Gooch, E. A., Horne, K.-L., Melzer, T. R., McAuliffe, M. J., MacAskill, M., Dalrymple‐Alford, J. C., Anderson, T.J., Theys, C. (2023). Acquired Stuttering in Parkinson's Disease. Movement Disorders Clinical Practice. 10.1002/mdc3.13758
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Download The New Zealand Parkinson’s Progression Programme.
MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Myall, D. J., Horne, K.-L., Shoorangiz, R., Almuqbel, M. M., Livingston, L., Grenfell, S., Pascoe, M. J., Marshall, E. T., Marsh, S., Perry, S. E., Meissner, W. G., Theys, C., Le Heron, C. J., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J. (2023). The New Zealand Parkinson’s Progression Programme. Journal of the Royal Society of New Zealand, 53, 466-488. 10.1080/03036758.2022.2111448
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2021

Download Higher perceived stress and exacerbated motor symptoms in Parkinson's disease during the COVID-19 lockdown in New Zealand.
Blakemore, R. L., Pascoe, M. J., Horne, K. L., Livingston, L., Young, B. N., Elias, B., Goulden, M., Grenfell, S., Myall, D. J., Pitcher, T. L., Dalrymple-Alford, J. C., Le Heron, C. J., Anderson, T. J., MacAskill, M. R. (2021). Higher perceived stress and exacerbated motor symptoms in Parkinson's disease during the COVID-19 lockdown in New Zealand. The New Zealand Medical Journal, 134, 44-51.
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Download Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it.
Horne, K., MacAskill, M. R., Myall, D. J., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple‐Alford, J. C. (2021). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. Movement Disorders Clinical Practice, 8, 390-399. 10.1002/mdc3.13151
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2020

Download Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease.
Myall, D.J., Horne, K., MacAskill, M.R., Livingston, L., Pitcher, T.L., Melzer, T.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2020). Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease. bioRxiv, 2020.05.31.1268. 10.1101/2020.05.31.126870
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2019

Download Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease.
Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K., Young, B., Pascoe, M., Almuqbel, M. A., Wang, J., Marsh, S., Miller, D. H., Dalrymple-Alford, J. C., Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease. Frontiers in Neurology, 10, 391. 10.3389/fneur.2019.00391
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2017

Download Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI).
Jones, A. J., Kuijer, R. G., Livingston, L., Myall, D., Horne, K., MacAskill, M., Pitcher, T., Barrett, P. T., Anderson, T. J., Dalrymple-Alford, J. C. (2017). Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI). Translational Neurodegeneration, 6(17). 10.1186/s40035-017-0085-5
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2016

Download Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Almuqbel, M., Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Wood, K., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. 10.1016/j.parkreldis.2015.11.008
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Download Different PD-MCI criteria and risk of dementia in Parkinson’s disease: Four year longitudinal study.
Wood, K., Myall, D.J., Livingston, L., Melzer, T.R., Pitcher, T.L., MacAskill, M.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson’s disease: Four year longitudinal study. npj Parkinson's Disease, 2, 15027. 10.1038/npjparkd.2015.27
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Abstracts and Short papers

2020

Download Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it.
Horne, K.-L., MacAskill, M. R., Myall, D., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple-Alford, J. C. (2020). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. MedRxiv, 2020, 09, 01, 20186312. https://doi.org/10.1101/2020.09.01.20186312
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2018

Horne, K. L., Myall, D. J., MacAskill, M. R., Anderson, T. J., Dalrymple-Alford, J. C.  (2018). Response to “Parkinson's disease mild cognitive impairment classifications and neurobehavioral symptoms” [letter]. International Psychogeriatrics. 10.1017/S1041610218000091

2016

Horne, K, Myall, DJ, Livingston, L, Grenfell, SF, Melzer, TR, Pitcher, TL, MacAskill, MR, Anderson, TJ, Dalrymple-Alford, JC (2016). Risk of dementia in Parkinson’s disease: Towards optimal short cognitive testing.  Proceedings of the 34th International Winter Conference on Brain Research, 1.
Melzer, TR, Keenan, RJ, Myall, DJ, Kaur, G, Livingston, L, Horne, K, Marsh, S, MacAskill, MR, Dalrymple-Alford, JC, Anderson, TJ (2016). Amyloid imaging and cognition in Parkinson’s disease: Interim report.  Proceedings of the 34th International Winter Conference on Brain Research, 3.

2014

Almuqbel, M., Melzer, T., Myall, D., MacAskill, M., Livingston, L., Wood, K., Pitcher, T., Dalrymple-Alford, J. , Anderson, T. (2014). Cognitive status in Parkinsons disease characterised by magnetic resonance spectroscopy.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,  32, 34.
Melzer, T., Myall, D., Livingston L., , Wood, K., Pitcher, T., Keenan, R., MacAskill, M., Dalrymple-Alford, J. , Anderson, T. (2014). White matter lesions - a factor in developing dementia in patients with Parkinsons disease.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand, 32, Abstract 3.5.
Myall, D., Wood, K., Livingston, L., Pitcher, T., Melzer, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Individualised medicine: Predicting dementia in Parkinsons disease.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,  32, Abstract 8.1.
Wood, K., Myall, D., Livingston, L., Melzer, T., Pitcher, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Comparing mild cognitive impairment criteria in Parkinsons disease: influence on dementia onset.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand, 32, Abstract 6.4.

2013

Dalrymple-Alford, J. C., Livingston, L., Melzer, T. R., Wood, K., Goh, T. J., Pitcher, T. L., Graham, C. F., Keenan, R. J., MacAskill, M. R. , Anderson, T.J. (2013). Current perspectives on Parkinsons disease: Cognition to the fore.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,  Volume 31, Abstract 29.
Wood, K., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Criteria for Parkinson’s disease with mild cognitive impairment associated with increased progression to dementia.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,  Volume 31, 58.