Imaging papers

2024

Download Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System.

Cornfeld, D., Condron, P., Newburn, G., McGeown, J., Scadeng, M., Bydder, M., ..., Melzer, T., ..., Bydder, G. (2024). Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System. Bioengineering, 11(5), 441. 10.3390/bioengineering11050441

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Download CADMUS: A Novel MRI-Based Classification of Spontaneous Intracerebral Hemorrhage Associated With Cerebral Small Vessel Disease.

Goeldlin, M. B., Mueller, M., Siepen, B. M., Zhang, W., Ozkan, H., Locatelli, M., ..., Wilson, D., ..., Swiss Stroke Registry Investigators and SIGNAL Investigators. (2024). CADMUS: A Novel MRI-Based Classification of Spontaneous Intracerebral Hemorrhage Associated With Cerebral Small Vessel Disease. Neurology, 102(1), e207977. 10.1212/WNL.0000000000207977

Download Dementia dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses.

Reuben, A, Richmond-Rakerd, LS, Milne, B., ..., Keenan, R., ..., Melzer, T., ..., Moffitt, T.E. (2024). Dementia dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses. Alzheimer's Dementia, 1-12. 10.1002/alz.13727

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Download Conscious but not thinking—Mind‐blanks during visuomotor tracking: An fMRI study of endogenous attention lapses.

Zaky, M. H., Shoorangiz, R., Poudel, G. R., Yang, L., Innes, C. R., Jones, R. D. (2024). Conscious but not thinking—Mind‐blanks during visuomotor tracking: An fMRI study of endogenous attention lapses. Human Brain Mapping, 45(11), e26781. 10.1002/hbm.26781

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2023

Download Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?

Barrett-Young, A., Abraham, W. C., Cheung, C. Y., Gale, J., Hogan, S., Ireland, D., ... , Melzer, T. , ... , Poulton, R. (2023). Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain? Eye and Brain, 25-35. 10.2147/EB.S402510

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Download Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis.

Murray, S.J., Almuqbel, M.M., Felton, S.A., Palmer, N.J., Myall, D.J., Shoorangiz, R., Ella, A., Keller, M., Palmer, D.N., Melzer, T.R. and Mitchell, N.L. (2023). Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis. Brain Communications, 5(1). 10.1093/braincomms/fcac339

Schwarz, G., Banerjee, G., Hostettler, I. C., Ambler, G., Seiffge, D. J., Ozkan, H., ..., Wilson, D., ..., Werring, D. J. (2023). MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage. International journal of stroke, 18(1), 85-94. 10.1177/17474930211062478

2022

Download Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: the MagNUM Study.

Poppe, T., Thompson, B., Boardman, J. P., Bastin, M. E., Alsweiler, J., Deib, G., Harding, J. E., Crowther, C. A., the MagNUM Study Group (2022). Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: the MagNUM Study. eBioMedicine, 103923 . 10.1016/j.ebiom.2022.103923

Download Multimodal neuroimaging with simultaneous fMRI and EEG. In N. V. Thakor (Ed.),.

Poudel, G. R., Jones, R. D. (2022). Multimodal neuroimaging with simultaneous fMRI and EEG. In N. V. Thakor (Ed.),. Handbook of Neuroengineering, Springer, Singapore. 10.1007/978-981-15-2848-4_81-1

Zhao, Y., Laansma, M. A., van Heese, E. M., Owens-Walton, C., Parkes, L. M., Debove, I., Rummel, C., Wiest, R., Cendes, F., Guimaraes, R., Yasuda, C. L., Wang, J.-J., Anderson, T. J., Dalrymple-Alford, J. C., Melzer, T. R., Pitcher, T. L., Schmidt, R., Schwingenschuh, P., Garraux, G., … for the ENIGMA consortium. (2022). Learning interpretable regularized ordinal models from 3D mesh data for neurodegenerative disease staging. In Abdulkadir, Bathula, Dvornek, Habes, Kia, Kumar, & Wolfers (Eds.),. Machine Learning in Clinical Neuroimaging, 13596, 115–124. 10.1007/978-3-031-17899-3_12

2021

Download Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease.

Basukala, D., Mukundan, R., Lim, A., Hurrell, M. A., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J., Myall, D. J., Melzer, T. R. (2021). Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease. Computers & Electrical Engineering, 91, 107091. 10.1016/j.compeleceng.2021.107091

Download Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort.

Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Langevin, S., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2021). Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and Psychopathology, 1–11. 10.1017/S0954579421000377

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Download Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.

Elliott, M. L., Caspi, A., Houts, R. M., Ambler, A., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R., Knodt, A., Leung, J. H., Melzer, T. R., Purdy, S. C., Ramrakha, S., Richmond-Rakerd, L. S., Righarts, A., Sugden, K., Thomson, W. M., Thorne, P. R., Williams, B. S., Wilson, G., Hariri, A. R., Poulton, R., Moffitt, T. E. (2021). Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy. Nature Aging, 1, 295-308. 10.1038/s43587-021-00044-4

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Download Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.

Elliott, M.L., Belsky, D.W., Knodt, A.R., Ireland, D., Melzer, T.R., Poulton, R., Ramrakha, S., Caspi, A., Moffitt, T.E. and Hariri, A.R. (2021). Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort. Molecular Psychiatry, 26, 3829–3838. 10.1038/s41380-019-0626-7

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Download A Hilbert-based method for processing respiratory timeseries.

Harrison, S. J., Bianchi, S., Heinzle, J., Stephan, K. E., Iglesias, S., Kasper, L. (2021). A Hilbert-based method for processing respiratory timeseries. NeuroImage, 230, 117787. 10.1016/j.neuroimage.2021.117787

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Download Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning.

Iglesias, S., Kasper, L., Harrison, S. J., Manka, R., Mathys, C., Stephan, K. E. (2021). Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning. NeuroImage, 226, 117590. 10.1016/j.neuroimage.2020.117590

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Download International multicenter analysis of brain structure across clinical stages of Parkinson’s disease.

Laansma, M. A., Bright, J. K., Al‐Bachari, S., Anderson, T. J., Ard, T., Assogna, F., Baquero, K. A., Berendse, H. W., Blair, J., Cendes, F., Dalrymple‐Alford, J. C., Bie, R. M. A., Debove, I., Dirkx, M. F., Druzgal, J., Emsley, H. C. A., Garraux, G., Guimarães, R. P., Gutman, B. A., Helmich, R. C., Klein, J. C., Mackay, C. E., McMillan, C. T., Melzer, T. R., Parkes, L. M., Piras, F., Pitcher, T. L., Poston, K. L., Rango, M., Ribeiro, L. F., Rocha, C. S., Rummel, C., Santos, L. S. R., Schmidt, R., Schwingenschuh, P., Spalletta, G., Squarcina, L., Heuvel, O. A., Vriend, C., Wang, J., Weintraub, D., Wiest, R., Yasuda, C. L., Jahanshad, N., Thompson, P. M., Werf, Y. D., The ENIGMA‐Parkinson’s Study. (2021). International multicenter analysis of brain structure across clinical stages of Parkinson’s disease. Movement Disorders , 36, 2583-2594. 10.1002/mds.28706

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Download Progression in Parkinson’s disease: a potpourri of plots and probabilities.

Le Heron, C., Myall, D., Anderson, T. (2021). Progression in Parkinson’s disease: a potpourri of plots and probabilities. Brain, 3, 708–711. 10.1093/brain/awab060

Download Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia.

Morgan, C. A., Melzer, T. R., Roberts, R. P., Wiebels, K., Mutsaerts, H. J. M. M., Spriggs, M. J., Dalrymple-Alford, J. C., Anderson, T. J., Cutfield, N. J., Deib, G., Pfeuffer, J., Addis, D. R., Kirk, I. J., Tippett, L. J. (2021). Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia. Scientific Reports, 11(1), 23325. 10.1038/s41598-021-02313-z

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Download Childhood self-control forecasts the pace of midlife aging and preparedness for old age.

Richmond-Rakerd, L. S., Caspi, A., Ambler, A., d’Arbeloff, T., de Bruine, M., Elliott, M., Harrington, H., Hogan, S., Houts, R. M., Ireland, D., Keenan, R., Knodt, A. R., Melzer, T. R., Park, S., Poulton, R., Ramrakha, S., Rasmussen, L. J. H., Sack, E., Schmidt, A. T., … Moffitt, T. E. (2021). Childhood self-control forecasts the pace of midlife aging and preparedness for old age. Proceedings of the National Academy of Sciences, 118, e2010211118. 10.1073/pnas.2010211118

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Download Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology.

Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., Moffitt, T. E., Caspi, A., Hariri, A. R. (2021). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry, 178. 10.1176/appi.ajp.2020.19090934

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Download Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making.

Saleh, Y., Le Heron, C., Petitet, P., Veldsman, M., Drew, D., Plant, O., Schulz, U., Sen, A., Rothwell, P. M., Manohar, S., Husain, M. (2021). Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making. Brain, 144, 1247–1262. 10.1093/brain/awab013

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Download Corticobasal syndrome: a practical guide.

Wilson, D., Le Heron, C., Anderson, T. (2021). Corticobasal syndrome: a practical guide. Practical Neurology, 21, 276–285. 10.1136/practneurol-2020-002835

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Download Midlife cardiovascular fitness is reflected in the brain’s white matter.

d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., Ramrakha, S., Poulton, R., Caspi, A., Moffitt, T. E., Hariri, A. R. (2021). Midlife cardiovascular fitness is reflected in the brain’s white matter. Frontiers in Aging Neuroscience, 13, 652575. 10.3389/fnagi.2021.652575

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2020

Download Compressed sensing in metal hip imaging: our experience.

Almuqbel, M., Melzer, T. R., Oram, B. J., Keenan, R. J. (2020). Compressed sensing in metal hip imaging: our experience. MAGNETOM Flash, 77, 4-8.

Banerjee, G., Chan, E., Ambler, G., Wilson, D., Cipolotti, L., Shakeshaft, C., ... , Werring, D. J. (2020). Cognitive impairment before atrial fibrillation–related ischemic events: neuroimaging and prognostic associations. Journal of the American Heart Association, 9(1), e014537.. 10.1161/JAHA.119.014537

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Download Challenges and future directions for representations of functional brain organization.

Bijsterbosch, J., Harrison, S. J., Jbabdi, S., Woolrich, M., Beckmann, C., Smith, S., Duff, E. P. (2020). Challenges and future directions for representations of functional brain organization. Nature Neuroscience, 23, 1484-1495. 10.1038/s41593-020-00726-z

Download Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: results of a randomised placebo-controlled trial.

Borlase, N., Melzer, T. R., Eggleston, M. J., Darling, K. A., Rucklidge, J. J. (2020). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: results of a randomised placebo-controlled trial. Nutritional Neuroscience , 23, 876-886. 10.1080/1028415X.2019.1574329

Download Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort.

Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2020). Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort. The Lancet Psychiatry, S22150366203000. 10.1016/S2215-0366(20)30002-X

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Darlow, B. A., Woodward, L. J., Levin, K. J., Melzer, T., Horwood, L. J. (2020). Perinatal and childhood predictors of general cognitive outcome at 28 years in a very‐low‐birthweight national cohort. Developmental Medicine & Child Neurology, 62(12), 1423-1428. 10.1111/dmcn.14649

Download The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants.

Fitzgibbon, S. P., Harrison, S. J., Jenkinson, M., Baxter, L., Robinson, E. C., Bastiani, M., ... , Andersson, J. (2020). The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants. NeuroImage, 223, 117303. 10.1016/j.neuroimage.2020.117303

Grasby, K. L. & Jahanshad, N. et al. (2020). The genetic architecture of the human cerebral cortex. Science, 367(6484), eaay6690. 10.1126/science.aay6690

Download Modelling subject variability in the spatial and temporal characteristics of functional modes.

Harrison, S. J., Bijsterbosch, J. D., Segerdahl, A. R., Fitzgibbon, S. P., Farahibozorg, S. R., Duff, E. P., ..., Woolrich, M. W. (2020). Modelling subject variability in the spatial and temporal characteristics of functional modes. NeuroImage, 222, 117226. 10.1016/j.neuroimage.2020.117226

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Lyndon, D., Davagnanam, I., Wilson, D., Jichi, F., Merwick, A., Bolsover, F., Jager, H. R., Cipolotti, C., Wheeler-Kingshott, C., Hughes, D., Murphy, E., Lachmann, R., Werring, D. J. (2020). MRI-visible perivascular spaces as an imaging biomarker in Fabry disease. Journal of Neurology, 1-7. 10.1007/s00415-020-10209-7

Download Test-retest reliability and sample size estimates after MRI scanner relocation.

Melzer, T.R., Keenan, R.J., Leeper, G.J., Kingston-Smith, S., Felton, S.A., Green, S.K., Henderson, K.J., Palmer, N.J., Shoorangiz, R., Almuqbel, M.M., Myall, D.J. (2020). Test-retest reliability and sample size estimates after MRI scanner relocation. Neuroimage 211, 116608. 10.1016/j.neuroimage.2020.116608

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Download Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology.

Romer, A.L., Elliott, M.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E., Caspi, A., Hariri, A.R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry. 10.1176/appi.ajp.2020.19090934

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Senadeera, S. C., Palmer, D. G., Keenan, R., Beharry, J., Yuh Lim, J., Hurrell, M. A., Mouthaan, P., Fink, J., Wilson, D., Lim, A., Wu, T. Y. (2020). Left atrial appendage thrombus detected during hyperacute stroke imaging is associated with atrial fibrillation. Stroke, 51, 3760-3764. 10.1161/STROKEAHA.120.030258

Download Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study.

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study. Disability and Rehabilitation, 42, 1942-1953. 10.1080/09638288.2018.1542461

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Download Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers.

Theys, C., Kovacs, S., Peeters, R., Melzer, T. R., van Wieringen, A., De Nil, L. F. (2020). Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers. PLOS One, 15(1), e0228452. 10.1371/journal.pone.0228452

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Wheelock, M. D., Lean, R. E., Bora, S., Melzer, T. R., Eggebrecht, A. T., Smyser, C. D., Woodward, L. J. (2020). Functional connectivity network disruption underlies domain-specific attention impairments in attention for children born very preterm. Cerebral Cortex. 10.1093/cercor/bhaa303

d'Arbeloff, T., Cooke, M., Knodt, A., Sison, M., Ramrakha, S., Keenan, R., Poulton, R., Hariri, A. R., Caspi, A., Moffitt, T. E. (2020). Better cardiovascular fitness is associated with better structural brain integrity in midlife: A population‐representative birth cohort study. Alzheimer's & Dementia, 16. 10.1002/alz.037983

Download White matter hyperintensities are common in midlife and already associated with cognitive decline.

d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T.J., Caspi, A., Moffitt, T. E., Hariri, A. R. (2020). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Communications, 1(1), fcz041. 10.1093/braincomms/fcz041

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2019

Download Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA.

Banerjee, G., Chan, E., Ambler, G., Wilson, D., Cipolotti, L., Shakeshaft, C., ..., Werring, D. J. (2019). Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. Journal of Neurology. 10.1007/s00415-019-09256-6

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Download Automated segmentation of substantia nigra and red nucleus in quantitative susceptibility mapping images.

Basukala, D., Mukundan, R., Melzer, T., Lim, A. (2019). Automated segmentation of substantia nigra and red nucleus in quantitative susceptibility mapping images. In 2019 20th International Conference on Parallel and Distributed Computing, Applications an.

Download Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: a preliminary functional magnetic resonance imaging study.

Douglas, K. M., Groves, S., Porter, R. J., Jordan, J., Wilson, L., Melzer, T. R., Wise, R. G., Bisson J. I., Bell, C. J. (2019). Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: a preliminary functional magnetic resonance imaging study. Australian & New Zealand Journal of Psychiatry, 53, 1167–1178. 10.1177/0004867419851860

Ella, A., Barrière, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9, 44–51. 10.1093/af/vfz024

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Download General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks.

Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516–532. 0.1016/j.neuroimage.2019.01.068

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Download Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease.

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K., Young, B., Pascoe, M., Almuqbel, M. A., Wang, J., Marsh, S., Miller, D. H., Dalrymple-Alford, J. C., Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease. Frontiers in Neurology, 10, 391. 10.3389/fneur.2019.00391

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Download Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults.

Pascoe, M.J., Melzer, T.R., Horwood, L.J., Woodward, L.J., Darlow, B.A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical, 22, 101780. 10.1016/j.nicl.2019.101780

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Download Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.

Romer, A.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E. and Caspi, A. (2019). Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Molecular Psychiatry, 1-8. 10.1038/s41380-019-0621-z

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Vergnet, S., Hives, F., Foubert-Samier, A., Payoux, P., Fernandez, P., Meyer, M., ..., Meissner, W. G. (2019). Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type. Parkinsonism & Related Disorders. 10.1016/j.parkreldis.2019.02.006

Download Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Wilson, D., Ambler, G., Lee, K. J., Lim, J. S., Shiozawa, M., Koga, M., Wong, Y. K. (2019). Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. The Lancet Neurology, 18(7), 653-665. 10.1016/S1474-4422(19)30197-8

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Yakushiji, Y., Wilson, D., Ambler, G., Charidimou, A., Beiser, A., van Buchem, M. A., ..., Imaizumi, T. (2019). Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis. Neurology, 92, e1086–97. 10.1212/WNL.0000000000007039

2018

Download MRI artefact in the rectum caused by ingested orthodontic brackets.

Almuqbel, M. M, Leeper, G. J., Petelo, J. F., Page, T. J., Melzer, T. R. (2018). MRI artefact in the rectum caused by ingested orthodontic brackets. Radiography, 24, e48-e50. 10.1016/j.radi.2017.10.002

Download Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI.

Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R., Melzer, T. R. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91:20170593, 1-5. 10.1259/bjr.20170593

Download Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis.

Castellazzi, G., Debernard, L., Melzer, T. R., Dalrymple-Alford, J. C., D’Angelo, E., Miller, D. H., Wheeler-Kingshott, C. A., Mason, D. F. (2018). Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis. Frontiers in Neurology, 9, 690. 10.3389/fneur.2018.00690

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Download Brain activation during processing of genuine facial emotion in depression: Preliminary findings.

Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., Johnston, L.C., Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders, 225, 91-96. 10.1016/j.jad.2017.07.049

Download Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.

Le Heron, C., Manohar, S., Plant, O., Muhammed, K., Griffanti, L., Nemeth, A., Husain, M. (2018). Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain, 141, 3193–3210. 10.1093/brain/awy257

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Download Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease.

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., Gray, S. J., Hughes, S. M., Palmer, D. N. (2018). Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26, 2366-2378. 10.1016/j.ymthe.2018.07.015

Download Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses.

Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., Barrell, G. K., Palmer, D.N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain and Behavior, 8, e01096. 10.1002/brb3.1096

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Tsivgoulis, G., Wilson, D., Katsanos, A. H., Sargento‐Freitas, J., Marques‐Matos, C., Azevedo, E., ... , Tomita, H. (2018). Neuroimaging and clinical outcomes of oral anticoagulant–associated intracerebral hemorrhage. Annals of Neurology, 84, 694-704. 10.1002/ana.25342

2017

Download Attention and regional gray matter development in very preterm children at age 12 years.

Lean, R. E., Melzer, T. R., Bora, S., Watts, R., Woodward, L. J. (2017). Attention and regional gray matter development in very preterm children at age 12 years. Journal of the International Neuropsychological Society, 23, 539-550. 10.1017/S1355617717000388

2016

Download Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.

Almuqbel, M., Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Wood, K., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. 10.1016/j.parkreldis.2015.11.008

2015

Download The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead.

Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead. BMC Pediatrics, 15, 90. 10.1186/s12887-015-0413-9

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Download Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis.

Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging. 10.1016/j.pscychresns.2015.10.00

Download Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness.

Innes, CRH, Kelly, PT, Hlavac, M, Melzer, TR, Jones, RD (2015). Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep, 38, 699-706. 10.5665/sleep.4658

Download Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease.

Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Watts, R., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLOS ONE, 10, e0143923. 10.1371/journal.pone.0143923

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2014

Download Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis.

Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A., Dalrymple-Alford, J. C., Miller, D. H. , Mason, D.F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 85. 10.1136/jnnp-2013-305612

Download Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.

Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C. , Anderson, T.J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study. Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. 10.1038/jcbfm.2014.40

Download Losing the struggle to stay awake: Divergent thalamic and cortical activity during microsleeps.

Poudel, G., Innes, C., Bones, P., Watts, R., Jones, R. (2014). Losing the struggle to stay awake: Divergent thalamic and cortical activity during microsleeps. Human Brain Mapping, 35, 257-269. 10.1002/hbm.22178

2013

Download Cross-Sectional Area of the Anterior Belly of the Digastric Muscle: Comparison of MRI and Ultrasound Measures.

Macrae, P., Jones, R., Myall, D., Melzer, T. , Huckabee, M. (2013). Cross-Sectional Area of the Anterior Belly of the Digastric Muscle: Comparison of MRI and Ultrasound Measures. Dysphagia, 28, 375-380. 10.1007/s00455-012-9443-8

Download The evolution of diffusion tensor imaging in Parkinson’s disease research.

Melzer, T. (2013). The evolution of diffusion tensor imaging in Parkinson’s disease research. Movement Disorders, 28, 1316. 10.1002/mds.25566

Download White matter microstructure deteriorates across cognitive stages in Parkinson disease.

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80, 1841-1849. 10.1212/WNL.0b013e3182929f62

Download Distinct neural correlates of time-on-task and transient errors during a visuomotor tracking task after sleep restriction.

Poudel, G. R., Innes, C. R. H., Jones, R.D. (2013). Distinct neural correlates of time-on-task and transient errors during a visuomotor tracking task after sleep restriction. NeuroImage, 77, 105-113.

2012

Download Grey matter atrophy in cognitively impaired Parkinson’s disease.

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 83(2), 188-194. 10.1186/2047-9158-1-17

Download Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study.

Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. 10.1186/2047-9158-1-17

Download Cerebral perfusion differences between drowsy and non-drowsy individuals following acute sleep restriction.

Poudel, G., Innes, C., Jones, R. (2012). Cerebral perfusion differences between drowsy and non-drowsy individuals following acute sleep restriction. Sleep, 35, 1085-1096. 10.5665/sleep.1994

2011

Download Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease.

Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., Shankaranarayanan, A., Alsop, D. C., Dalrymple-Alford, J. C., Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease. Brain, 134(3), 845-855. 10.1093/brain/awq377

2010

Download Measurement of BOLD changes due to cued eye-closure and stopping during a continuous visuomotor task via model-based and model-free approaches.

Poudel, G. R., Jones, R. D., Innes, C. R. H., Davidson, P. R., Bones, P., Watts, R. (2010). Measurement of BOLD changes due to cued eye-closure and stopping during a continuous visuomotor task via model-based and model-free approaches. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 18(5), 479-488. 10.1109/TNSRE.2010.2050782

2008

Download Bio-medical X-ray imaging with spectroscopic pixel detectors.

Butler, A., Anderson, N., Tipples, R., Cook, N., Watts, R., Meyer, J., Bell, A., Melzer, T., Butler, P. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 591, 141-146. 10.1016/j.nima.2008.03.039

Download MRI with TRELLIS: a novel approach to motion correction.

Maclaren, J. R., Bones, P. J., Millane, R. P., Watts, R. (2008). MRI with TRELLIS: a novel approach to motion correction. Magnetic Resonance Imaging, 26(4), 474-483. 10.1016/j.mri.2007.08.013

Download Spectroscopic biomedical imaging with the Medipix2 detector.

Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., Butler, P.H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Science in Medicine, 31(4), 300-306.

2006

Download Distribution of microstructural damage in the brains of professional boxers: A diffusion MRI study.

Chappell, M. H., Ulug, A. M., Zhang, L., Heitger, M. H., Jordan, B. D., Zimmerman, R. D. , Watts, R. (2006). Distribution of microstructural damage in the brains of professional boxers: A diffusion MRI study. Journal of Magnetic Resonance Imaging, 24, 537-42. 10.1002/jmri.20656

Download 3D models of blood flow in the cerebral vasculature.

Moore, S., David, T., Chase, J., Arnold, J., Fink, J. (2006). 3D models of blood flow in the cerebral vasculature. Journal of Biomechanics, 39, 1454-1463. 10.1016/j.jbiomech.2005.04.005