Dr Ross Keenan

FRANZCR

Consultant Neuroradiologist

Pacific Radiology Group,

Consultant Neuroradiologist

New Zealand Brain Research Institute, Christchurch

Publications

Provided on request for non-commercial personal use by researchers.

2021

Download Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease.
Basukala, D., Mukundan, R., Lim, A., Hurrell, M. A., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J., Myall, D. J., Melzer, T. R. (2021). Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease. Computers & Electrical Engineering, 91, 107091. 10.1016/j.compeleceng.2021.107091
Download Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy.
Elliott, M. L., Caspi, A., Houts, R. M., Ambler, A., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R., Knodt, A., Leung, J. H., Melzer, T. R., Purdy, S. C., Ramrakha, S., Richmond-Rakerd, L. S., Righarts, A., Sugden, K., Thomson, W. M., Thorne, P. R., Williams, B. S., Wilson, G., Hariri, A. R., Poulton, R.,  Moffitt, T. E. (2021). Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy. Nature Aging, 1, 295-308. 10.1038/s43587-021-00044-4
Download Childhood self-control forecasts the pace of midlife aging and preparedness for old age.
Richmond-Rakerd, L. S., Caspi, A., Ambler, A., d’Arbeloff, T., de Bruine, M., Elliott, M., Harrington, H., Hogan, S., Houts, R. M., Ireland, D., Keenan, R., Knodt, A. R., Melzer, T. R., Park, S., Poulton, R., Ramrakha, S., Rasmussen, L. J. H., Sack, E., Schmidt, A. T., … Moffitt, T. E. (2021). Childhood self-control forecasts the pace of midlife aging and preparedness for old age. Proceedings of the National Academy of Sciences, 118, e2010211118. 10.1073/pnas.2010211118
Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., Moffitt, T. E., Caspi, A., Hariri, A. R. (2021). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry, 178. 10.1176/appi.ajp.2020.19090934

2020

Download Compressed sensing in metal hip imaging: our experience.
Almuqbel, M., Melzer, T. R., Oram, B. J., Keenan, R. J. (2020). Compressed sensing in metal hip imaging: our experience. MAGNETOM Flash, 77.
Download Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease.
Borlase, N., Myall, D., Melzer, T., Livingston, L., Watts, R., Keenan, R., MacAskill, M., Anderson, T., Dalrymple-Alford, J. (2020). Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease. bioRxiv, 2020.05.21.1096. 10.1101/2020.05.21.109660
Download Test-retest reliability and sample size estimates after MRI scanner relocation.
Melzer, T.R., Keenan, R.J., Leeper, G.J., Kingston-Smith, S., Felton, S.A., Green, S.K., Henderson, K.J., Palmer, N.J., Shoorangiz, R., Almuqbel, M.M., Myall, D.J. (2020). Test-retest reliability and sample size estimates after MRI scanner relocation. Neuroimage 211, 116608. 10.1016/j.neuroimage.2020.116608
Download Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The magnum study.
Poppe, T., Thompson, B., Boardman, J. P., Bastin, M. E., Alsweiler, J., Deib, G., Harding, J. E., Crowther, C. A., for the MagNUM Study Group  (2020). Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The magnum study. EBioMedicine, 59. 10.1016/j.ebiom.2020.102957
Download Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology.
Romer, A.L., Elliott, M.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E., Caspi, A., Hariri, A.R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry. 10.1176/appi.ajp.2020.19090934
Senadeera, S. C., Palmer, D. G., Keenan, R., Beharry, J., Yuh Lim, J., Hurrell, M. A., Mouthaan, P., Fink, J., Wilson, D., Lim, A., Wu, T. Y. (2020). Left atrial appendage thrombus detected during hyperacute stroke imaging is associated with atrial fibrillation. Stroke, 51, 3760-3764. 10.1161/STROKEAHA.120.030258
Download White matter hyperintensities are common in midlife and already associated with cognitive decline.
d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T.J., Caspi, A., Moffitt, T. E., Hariri, A. R. (2020). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Communications, 1(1), fcz041. 10.1093/braincomms/fcz041

2019

Download General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks.
Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516–532. 0.1016/j.neuroimage.2019.01.068
Download Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease.
Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K., Young, B., Pascoe, M., Almuqbel, M. A., Wang, J., Marsh, S., Miller, D. H., Dalrymple-Alford, J. C., Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease. Frontiers in Neurology, 10, 391. 10.3389/fneur.2019.00391
Download Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.
Romer, A.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E. and Caspi, A. (2019). Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Molecular Psychiatry, 1-8. 10.1038/s41380-019-0621-z

2018

Download Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI.
Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R., Melzer, T. R. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91:20170593, 1-5. 10.1259/bjr.20170593

2016

Download Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Almuqbel, M., Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Wood, K., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. 10.1016/j.parkreldis.2015.11.008

2015

Download The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead.
Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead. BMC Pediatrics, 15, 90. 10.1186/s12887-015-0413-9
Download Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease.
Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Watts, R., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLOS ONE, 10, e0143923. 10.1371/journal.pone.0143923

2014

Download Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.
Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C. , Anderson, T.J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.  Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. 10.1038/jcbfm.2014.40

2013

Download White matter microstructure deteriorates across cognitive stages in Parkinson disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80, 1841-1849. 10.1212/WNL.0b013e3182929f62

2012

Download Grey matter atrophy in cognitively impaired Parkinson’s disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 83(2), 188-194. 10.1186/2047-9158-1-17
Download Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study.
Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. 10.1186/2047-9158-1-17

2011

Download Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease.
Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., Shankaranarayanan, A., Alsop, D. C., Dalrymple-Alford, J. C., Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease. Brain,  134(3), 845-855. 10.1093/brain/awq377

2010

Download The MoCA: Well-suited screen for cognitive impairment in Parkinson’s disease.
Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., Anderson, T.J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson’s disease. Neurology, 75, 1717-1725. 10.1212/WNL.0b013e3181fc29c9

Abstracts and Short papers

2020

d'Arbeloff, T., Cooke, M., Knodt, A., Sison, M., Ramrakha, S., Keenan, R., Poulton, R., Hariri, A. R., Caspi, A., Moffitt, T. E. (2020). Better cardiovascular fitness is associated with better structural brain integrity in midlife: A populationā€representative birth cohort study. Alzheimer's & Dementia, 16. 10.1002/alz.037983

2019

d'Arbeloff, T., Elliott, M., Knodt, A., Melzer, T., Keenan, R., Ireland, D., … & Hariri, A. (2019). White matter lesions are common in midlife and associated with cognitive decline. Biological Psychiatry, 85(10), S213. 10.1016/j.biopsych.2019.03.539

2018

Download Segmentation of substantia nigra using weighted thresholding method, In 2018 International Conference on Image and Vision Computing New Zealand (IVCNZ) (pp.
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra using weighted thresholding method, In 2018 International Conference on Image and Vision Computing New Zealand (IVCNZ) (pp. 1-6).
Download Segmentation of substantia nigra for the automated characterization of Parkinson’s disease.
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra for the automated characterization of Parkinson’s disease. In 2018 IEEE International Conference on Image Processing, Applications an.

2016

Melzer, TR, Keenan, RJ, Myall, DJ, Kaur, G, Livingston, L, Horne, K, Marsh, S, MacAskill, MR, Dalrymple-Alford, JC, Anderson, TJ (2016). Amyloid imaging and cognition in Parkinson’s disease: Interim report.  Proceedings of the 34th International Winter Conference on Brain Research, 3.

2015

Melzer, TR, Myall, DJ, MacAskill, MR, Livingston, L, Pitcher, TL, Watts, R, Keenan, RJ, Dalrymple-Alford, JC, Anderson, TJ (2015). White matter lesions contribute to future dementia in Parkinson’s disease. Proceedings of the 21st Annual Meeting of the Organization for Human Brain Mapping.

2014

Melzer, T., Myall, D., Livingston L., , Wood, K., Pitcher, T., Keenan, R., MacAskill, M., Dalrymple-Alford, J. , Anderson, T. (2014). White matter lesions - a factor in developing dementia in patients with Parkinsons disease.  Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand, 32, Abstract 3.5.

2013

Dalrymple-Alford, J. C., Livingston, L., Melzer, T. R., Wood, K., Goh, T. J., Pitcher, T. L., Graham, C. F., Keenan, R. J., MacAskill, M. R. , Anderson, T.J. (2013). Current perspectives on Parkinsons disease: Cognition to the fore.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,  Volume 31, Abstract 29.
Dalrymple-Alford, J., McCurrie, C., Anderson, T., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R. , Melzer, T. (2013). Domain specific cognitive dysfunction in Parkinson’s Disease and associated pattern of grey matter atrophy.  Proceedings of the Movement Disorders Society 17th International Congress - Sydney, Abstract 572..
Grenfell, S., Melzer, T. R., Young, B., Wang, A, Livingston, L., Keenan, R. J., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Reduced default mode network connectivity and autobiographical memory in mild cognitive impairment.  Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown, Volume 31, Abstract 27.
Melzer, T. R., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R., Dalrymple-Alford, J. , Anderson, T. (2013). Serial DTI and cognitive decline in Parkinsons disease. Proceedings of the Movement Disorders Society 17th International Congress, Sydney,  Movement Disorders, 28 Supplement 1, 555.