Dr Campbell Le Heron

MBChB, FRACP, DPhil

Consultant Neurologist

Department of Neurology, Canterbury District Health Board, Christchurch

Cognitive Neuroscientist

New Zealand Brain Research Institute, Christchurch

Clinical Senior Lecturer

Department of Medicine, University of Otago, Christchurch

 

I am a Neurologist and Cognitive Neuroscientist with a strong interest in cognitive disorders and the normal neural processes that underlie these deficits. My recent research has focussed on understanding the mechanisms that underlie apathy – a disorder of motivation with often debilitating consequences – in various neurological disorders including Parkinson’s disease, cerebral small vessel disease and Huntington’s disease. I use specifically designed behavioural paradigms, physiological recordings (e.g. of pupillary responses to reward) and imaging techniques (including fMRI, diffusion imaging and arterial spin labelling) to investigate whether apathy is caused by disruption of normal decision making processes – particularly the integration of reward information and action costs to drive choice. My work is heavily influenced by basic neuroscience developments, which I aim to translate to the clinical context. In turn, by studying patients with disorders of cognition I also aim to improve understanding of these underlying normal processes.
 
Following completion of Neurology specialist training in 2014 I undertook a DPhil at the University of Oxford in Professor Masud Husain’s cognitive neurology research group. I have now returned to New Zealand where I work as a Neurologist specialising in Cognitive and Movement disorders, and am developing a research program centred on understanding neurobehavioural disorders and the complex neural interplay between cortical and subcortical regions that leads to the generation (or not) of actions.

 

October 2019: I have a Post-doctoral position available!

I have funding to employ a post-doctoral researcher full-time for one year beginning early 2020, to investigate patient trajectories and antecedent causes of apathy in people with Parkinson’s disease. The project is based at the NZBRI, where a longitudinal cohort of Parkinson’s patients has been followed since 2007, including extensive imaging, neuropsychology and clinical measures. Data is already collected, and the role will predominantly involve leading the analysis and interpretation of results.

Download the job description.


Affiliations:

  • New Zealand Brain Research Institute
  • Department of Medicine, University of Otago, Christchurch
  • Department of Neurology, Canterbury District Health Board
  • Cognitive Neurology Research Group, Nuffield Dept of Clinical Neurosciences, Oxford, UK
  • Motivation and Social Neuroscience Lab, Oxford, UK

 

Scholarships and Grants:

  • 2019 – Canterbury Medical Research Fund (CMRF) Major Project Grant
  • 2014 – Christopher Welch Scholarship in Biological Sciences, University of Oxford
  • 2014 – Clarendon Scholarship, University of Oxford

 

Publications

Provided on request for non-commercial personal use by researchers.

2019

Download Brain mechanisms underlying apathy.
Le Heron, C. J., Holroyd, C., Salamone, J., Husain, M. (2019). Brain mechanisms underlying apathy. Journal of Neurology, Neurosurgery and Psychiatry, 90, 302-312. 10.1136/jnnp-2018-318265
Download Automated lesion segmentation with BIANCA: impact of population-level features, classification algorithm and locally adaptive thresholding.
Sundaresan, V., Zamboni, G., Le Heron, C., Rothwell, P. M., Husain, M., Battaglini, M., ... , Griffanti, L. (2019). Automated lesion segmentation with BIANCA: impact of population-level features, classification algorithm and locally adaptive thresholding. Neuroimage, 202, 116056. 10.1016/j.neuroimage.2019.116056

2018

Download Dopamine modulates option generation for behavior.
Ang, Y. S., Manohar, S., Plant, O., Kienast, A., Le Heron, C., Muhammed, K., Hu, M., Husain, M. (2018). Dopamine modulates option generation for behavior. Current Biology, 28, 1561-1569. 10.1016/j.cub.2018.03.069
Download The anatomy of apathy: a neurocognitive framework for amotivated behaviour.
Le Heron, C., Apps, M. A. J., Husain, M. (2018). The anatomy of apathy: a neurocognitive framework for amotivated behaviour. Neuropsychologia, 118, 54-67. 10.1016/j.neuropsychologia.2017.07.003
Download Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.
Le Heron, C., Manohar, S., Plant, O., Muhammed, K., Griffanti, L., Nemeth, A., Husain, M. (2018). Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain, 141, 3193–3210. 10.1093/brain/awy257
Download Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson’s disease.
Le Heron, C., Plant, O., Manohar, S., Ang, Y. S., Jackson, M., Lennox, G., Hu, M, Husain, M. (2018). Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson’s disease. Brain, 141, 1455-1469. 10.1093/brain/awy110

2014

Hassan, I. K., Looi, J. C., Velakoulis, D., Gaillard, F., Lui, E. H., O’Brien, T. J., French, C, Le Heron, C. J., Adams, S. J. (2014). Psychosis with obsessive-compulsive symptoms in tuberous sclerosis.  Journal of Clinical Neuroscience,  21, 867-869. 10.1016/j.jocn.2013.08.005
Le Heron, C. J., Fang, K., Gubbi, J., Churilov, L., Palaniswami, M., Davis, S., Yan, B. (2014). Wireless accelerometry is feasible in acute monitoring of upper limb motor recovery after ischemic stroke. Cerebrovascular Diseases,  37, 336-341. 10.1159/000360808
Download Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.
Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C. , Anderson, T.J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.  Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. 10.1038/jcbfm.2014.40

2007

Muthu, C., Chu, J. J., Le Heron, C., Roake, J. A., Lewis, D. R. (2007). Patient awareness of risk factors for peripheral vascular disease. Annals of Vascular Surgery,  21(4), 433-437. 10.1016/j.avsg.2006.06.007

2005

Download Memory-guided saccades in Parkinson's disease: long delays can improve performance.
Le Heron, C. J., MacAskill, M. R. , Anderson, T.J. (2005). Memory-guided saccades in Parkinson's disease: long delays can improve performance. Experimental Brain Research, 161, 293-298. 10.1007/s00221-004-2071-2

2004

Iles, S., Le Heron, C. J., Davies, G., Turner, J. G., Beckert, L. E. (2004). ECG score predicts those with the greatest percentage of perfusion defects due to acute pulmonary thromboembolic disease.  Chest,  125(5), 1651-1656. 10.1378/chest.125.5.1651