Assoc Prof Tracy Melzer
PhD
Associate Professor
Te Kura Mahi ā-Hirikapo | School of Psychology, Speech and Hearing, University of Canterbury, Christchurch
Imaging Research Manager
New Zealand Brain Research Institute, Christchurch
Current Role
As Imaging Research Manager, I oversee all imaging at the NZBRI. This provides me with the opportunity to become involved in a wide range of neurological research.
As an Associate Professor in Te Kura Mahi ā-Hirikapo | School of Psychology, Speech and Hearing, University of Canterbury, my teaching responsibilities include Neuroscience of Communication and Speech and Applied Neuroscience: Brain Imaging. My primary research interests focus on the development and application of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) techniques to advance our understanding of cognitive decline in Parkinson’s disease.
Research Interests
- MRI (structural, diffusion, perfusion, functional)
Metabolic and amyloid PET imaging (positron emission tomography)
Parkinson’s disease
Cognitive impairment
Education
- PhD in Medicine, University of Otago, NZ
- BSc (Hons) in Medical Physics, University of Canterbury, NZ
- BA (Hons) in Physics, University of Montana, USA
Interests
- Spending time with my wife and two daughters
- Fishing
- Running
- Tramping
- Cycling
Projects
- Tracking Parkinson’s disease progression over the long term
- Cerebrovascular health in Parkinson’s disease
Link to Associate Professor Tracy Melzer's Google Scholar page
Publications
Provided on request for non-commercial personal use by researchers.
2025
Bydder, M., Cornfeld, D. M., Melzer, T. R., Condron, P., Newburn, G., Kwon, E. E., ... , Bydder, G. M. (2025). Log subtracted inversion recovery. Magnetic Resonance Imaging, .
10.1016/j.mri.2025.110328
Cornfeld, D. M., Condron, P., Bydder, M., Melzer, T. R., Pravatà, E., Port, J. D., ... , Bydder, G. (2025). Ultra-High Contrast MRI of the Brain and Spinal Cord using Directly Acquired and Synthetic BipoLAr Inversion Recovery (BLAIR) Images, Preprints. Preprints.org.
10.20944/preprints202505.2380.v5
Harris, S. L., Woodward, L. J., Horwood, L. J., Melzer, T. R., Bora, S., Pascoe, M., Darlow, B. A. (2025). Visuospatial outcomes of a prospective national cohort of young adults with very low birthweight. Pediatric research, .
10.1038/s41390-025-03890-9
Murray, S.J., Almuqbel, M.M., Felton, S.A., Palmer, N.J., Deane, A.R., Myall, D.J., Shoorangiz, R., Ella, A., Keller, M., Palmer, D.N., Melzer, T.R., Mitchell, N.L. (2025). Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep. Brain and Behavior,
15, .
10.1002/brb3.70431
Roalf, D., Basner, M., Beer, J. C., Shinohara, R. T., Ruparel, K., Moore, T. M., ..., ..., Melzer, T.R., Taylor, B.V., Gur, R. C. (2025). Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition. npj Microgravity,
11(1), .
10.1038/s41526-025-00497-6
Shawa, Z., Shand, C., Taylor, B., Berendse, H.W., ..., ..., Melzer, T.R., Pitcher, T.L., Anderson, T.J., Dalrymple-Alford, J.C., ..., ..., ENIGMA Parkinson’s Disease Working Group (2025). Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson’s disease. Brain communications,
7(2), .
10.1093/braincomms/fcaf146
Tetereva, A., Knodt, A.R., Melzer, T.R., van der Vliet, W., Gibson, B., Hariri, A.R., Whitman, E.T., Li, J., Lal Khakpoor, F., Deng, J. and Ireland, D. (2025). Improving predictability, reliability, and generalizability of brain-wide associations for cognitive abilities via multimodal stacking. PNAS Nexus,
4(6), .
10.1093/pnasnexus/pgaf175
Whitman, E.T., Elliott, M.L., Knodt, A.R., Abraham, W.C., Anderson, T.J., Cutfield, N.J., Hogan, S., Ireland, D., Melzer, T.R., Ramrakha, S. and Sugden, K. (2025). DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease. Nature Aging, .
10.1038/s43587-025-00897-z
2024
Aye, W. W., Stark, M. R., Horne, K.-L., Livingston, L., Grenfell, S., Myall, D. J., Pitcher, T.L., Almuqbel, M.M., Keenan, R. J., Meissner, W.G., Dalrymple-Alford, J., Anderson, T.J., Le Heron, C., Melzer, T. R. (2024). Early‐phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(2),
e12601..
10.1002/dad2.12601
Buckley, R. J., Innes, C. R. H., Kelly, P. T., Hlavac, M. C., Beckert, L., Melzer, T. R., Jones, R. D. (2024). Cerebral perfusion is not impaired in persons with moderate obstructive sleep apnoea when awake. Sleep and Breathing,
Online, .
10.1007/s11325-024-03048-7
Bydder, M., Ali, F., Condron, P., Cornfeld, D.M., Newburn, G., Kwon, E.E., Tayebi, M., Scadeng, M., Melzer, T.R., Holdsworth, S.J. and Bydder, G.M. (2024). Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T1 phantom. NMR in Biomedicine, 37(12),
p.e5269..
10.1002/nbm.5269
Condron, P., Cornfeld, D. M., Scadeng, M., Melzer, T. R., Newburn, G., Bydder, M., ... , Bydder, G. M. (2024). Ultra-High Contrast MRI: The Whiteout Sign Shown with Divided Subtracted Inversion Recovery (dSIR) Sequences in Post-Insult Leukoencephalopathy Syndromes (PILS). Tomography,
10(7), .
10.3390/tomography10070074
Cornfeld, D., Condron, P., Newburn, G., McGeown, J., Scadeng, M., Bydder, M., ..., Melzer, T., ..., Bydder, G. (2024). Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System. Bioengineering,
11(5), .
10.3390/bioengineering11050441
Gooch, E., Melzer, T.R., Horne, K.L., Grenfell, S., Livingston, L., Pitcher, T., Dalrymple-Alford, J.C., Anderson, T.J., McAuliffe, M.J., Theys, C. (2024). Higher Frequency of Stuttered Disfluencies Negatively Affects Communicative Participation in Parkinson's Disease. Journal of Speech Language and Hearing Research, .
10.1044/2024_JSLHR-24-00018
Henley, S., Spriggs, N., Kabaliuk, N., Stitt, D., Swale, A., Xu, C., Mangan, K., Hamlin, M., Masters, R., Melzer, T., Anderson, T., Snell, D., Clark, A., Alexander, K., Holdsworth, S., Draper, N. (2024). Effects of One Season of Rugby on the Neurological Integrity of Adolescent Players. .
Kennedy, E., Liebel, S.W., Lindsey, H.M, ..., Anderson, T.J, ..., Dalrymple-Alford, J.C, ..., Melzer, T.R., ..., Myall, D.J, ..., Dennis, E.L. (2024). Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis. Brain Sciences,
14(7), .
10.3390/brainsci14070669
Laansma, M.A., Zhao, Y., van Heese, E.M., Bright, J.K., Owens-Walton, C., Al-Bachari, S., Anderson, T.J., ..., ..., Dalrymple-Alford, J.C., ..., ..., Melzer, T.R., ..., ..., Pitcher, T.L., ..., ..., Gutman, B.A. (2024). A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease. npj Parkinson's Disease,
10(1), .
10.1038/s41531-024-00825-9
Le Heron, C., Horne, K. L., MacAskill, M. R., Livingston, L., Melzer, T. R., Myall, D., Pitcher, T., Dalrymple-Alford, J., Anderson, T., Harrison, S. (2024). Cross-Sectional and Longitudinal Association of Clinical and Neurocognitive Factors With Apathy in Patients With Parkinson Disease. Neurology,
102(12), .
10.1212/WNL.0000000000209301
Newburn, G., Condron, P., Kwon, E. E., McGeown, J. P., Melzer, T. R., Bydder, M., ..., .., Bydder, G. M. (2024). Diagnosis of Delayed Post-Hypoxic Leukoencephalopathy (Grinker’s Myelinopathy) with MRI Using Divided Subtracted Inversion Recovery (dSIR) Sequences: Time for Reappraisal of the Syndrome? Diagnostics,
14(4), .
2075-4418/14/4/418
Owens-Walton, C., Nir, T. M., Al-Bachari, S., Ambrogi, S., Anderson, T. J., Aventurato, I. K., ..., Dalrymple-Alford, J.C, ..., Melzer, T.R, ..., Pitcher, T.L., ..., van der Werf, Y. D. (2024). A Worldwide Study of White Matter Microstructural Alterations in People Living with Parkinson's Disease. medRxiv, .
10.1101/2024.01.16.24301235
Reuben, A, Richmond-Rakerd, LS, Milne, B., ..., Keenan, R., ..., Melzer, T., ..., Moffitt, T.E. (2024). Dementia dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses. Alzheimer's Dementia, .
10.1002/alz.13727
Slater, N., Melzer, T.R., Myall, D.J., Anderson, T.J., Dalrymple-Alford, J.C. (2024). Cholinergic basal forebrain integrity and cognition in Parkinson’s disease: a re-appraisal of MRI evidence. Movement Disorders,
12, .
10.1002/mds.30023
Tahara‐Eckl, L.T., Morgan, C.A., Roberts, R.P., Dell'Acqua, F., Kirk, I.J., Melzer, T.R., Dalrymple‐Alford, J.C., Anderson, T.J., Cutfield, N.J. and Tippett, L.J. (2024). Investigation of structural connectivity in the whole brain and frontoparietal network in groups at risk of Alzheimer’s disease dementia. Alzheimer's & Dementia, .
10.1002/alz.094761
Tetereva, A., Knodt, A.R., Melzer, T.R., van der Vliet, W., Gibson, B., Hariri, A.R., Whitman, E.T., Li, J., Deng, J., Ireland, D. and Ramrakha, S. (2024). Improving Predictability, Reliability and Generalisability of Brain-Wide Associations for Cognitive Abilities via Multimodal Stacking. bioRxiv.
10.1101/2024.05.03.589404
Theys, C., Jaakkola, E., Melzer, T. R., De Nil, L. F., Guenther, F. H., Cohen, A. L., ... , Joutsa, J. (2024). Localization of stuttering based on causal brain lesions. Brain,
147(6), .
0.1093/brain/awae059
Vashistha, R., Almuqbel, M.M., Palmer, N.J., Keenan, R.J., Gilbert, K., Wells, S., Lynch, A., Li, A., Kingston‐Smith, S., Melzer, T.R. and Koerzdoerfer, G. (2024). Evaluation of deep‐learning TSE images in clinical musculoskeletal imaging. Journal of Medical Imaging and Radiation Oncology.
10.1111/1754-9485.13714
Whitman, E. T., Ryan, C. P., Abraham, W. C., Addae, A., Corcoran, D. L., Elliott, M. L., ..., ..., Melzer, T.P, ..., ..., Caspi, A. (2024). A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts. Neurobiology of Aging,
136, .
10.1016/j.neurobiolaging.2024.01.008
Whitman, E.T., Elliott, M.L., Knodt, A.R., Abraham, W.C., Anderson, T.J., Cutfield, N., Hogan, S., Ireland, D., Melzer, T.R., Ramrakha, S. and Sugden, K., 2024. (2024). An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality. bioRxiv.
10.1101/2024.08.19.608305v1
2023
Barrett-Young, A., Abraham, W. C., Cheung, C. Y., Gale, J., Hogan, S., Ireland, D., ... , Melzer, T. , ... , Poulton, R. (2023). Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain? Eye and Brain, .
10.2147/EB.S402510
Dalrymple-Alford, J.C., Anderson, T.J., Melzer, T.R. (2023). Thalamus, thalamocortical networks, and non-motor symptoms in Parkinson’s disease. book chapter in Cerebral Cortex and Thalamus XII.
Gooch, E. A., Horne, K.-L., Melzer, T. R., McAuliffe, M. J., MacAskill, M., Dalrymple‐Alford, J. C., Anderson, T.J., Theys, C. (2023). Acquired Stuttering in Parkinson's Disease. Movement Disorders Clinical Practice.
10.1002/mdc3.13758
Kennedy, E., Vadlamani, S., Lindsey, H. M., Lei, P. W., Pugh, M. J., Adamson, M., ... , Anderson, T.J., ... , Dalrymple-Alford, J.C., ... , Melzer, T.R, ... , Myall, D.J., ... , Wilde, E. A. (2023). Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium. bioRxiv, .
10.1101/2023.01.16.524331
Kerestes, R., Laansma, M., ..., Anderson, T., ..., Dalrymple-Alford, J., ..., Melzer, T., ..., Pitcher, T., ..., the ENIGMA-Parkinson's Study (2023). Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study. Movement Disorders.
10.1002/mds.29611
MacAskill, M. R., Pitcher, T. L., Melzer, T. R., Myall, D. J., Horne, K.-L., Shoorangiz, R., Almuqbel, M. M., Livingston, L., Grenfell, S., Pascoe, M. J., Marshall, E. T., Marsh, S., Perry, S. E., Meissner, W. G., Theys, C., Le Heron, C. J., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J. (2023). The New Zealand Parkinson’s Progression Programme. Journal of the Royal Society of New Zealand,
53, .
10.1080/03036758.2022.2111448
Morris, L. A., Harrison, S. J., Melzer, T. R., Dalrymple-Alford, J. C., Anderson, T. J., MacAskill, M. R., Le Heron, C. J. (2023). Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease. Brain,
awad113.
10.1093/brain/awad113
Murray, S.J., Almuqbel, M.M., Felton, S.A., Palmer, N.J., Myall, D.J., Shoorangiz, R., Ella, A., Keller, M., Palmer, D.N., Melzer, T.R. and Mitchell, N.L. (2023). Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis. Brain Communications,
5(1).
10.1093/braincomms/fcac339
Whitman, E. T., Knodt, A. R., Elliott, M. L., Abraham, W. C., Cheyne, K., Hogan, S., Ireland, D., Keenan, R., Leung, J. H., Melzer, T. R., Poulton, R., Purdy, S. C., Ramrakha, S., Thorne, P. R., Caspi, A., Moffitt, T. E., Hariri, A. R. (2023). Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities. Cerebral Cortex.
10.1093/cercor/bhad109
2022
Morgan, C.A., Roberts, R.P., Chaffey, T., Tahara-Eckl, L., van der Meer, M., Günther, M., Anderson, T.J., Cutfield, N.J., Dalrymple-Alford, J.C., Kirk, I.J., Addis, D R., Tippett, L.J., Melzer, T.R. (2022). Reproducibility and repeatability of magnetic resonance imaging in dementia. Physica Medica,
101, .
doi.org/10.1016/j.ejmp.2022.06.012
Poppe, T., Thompson, B., Boardman, J. P., Bastin, M. E., Alsweiler, J., Deib, G., Harding, J. E., Crowther, C. A., the MagNUM Study Group (2022). Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: the MagNUM Study. eBioMedicine,
103923 .
10.1016/j.ebiom.2022.103923
Tippett, L. J., Cawston, E. E., Morgan, C. A., Melzer, T. R., Brickell, K. L., Ilse, C., Cheung, G., Kirk, I. J., Roberts, R. P., Govender, J., Griner, L., Le Heron, C., Buchanan, S., Port, W., Dudley, M., Anderson, T. J., Williams, J. M., Cutfield, N. J., Dalrymple-Alford, J. C., … the NZ-DPRC. (2022). Dementia Prevention Research Clinic: A longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa. Journal of the Royal Society of New Zealand.
10.1080/03036758.2022.2098780
Zhao, Y., Laansma, M. A., van Heese, E. M., Owens-Walton, C., Parkes, L. M., Debove, I., Rummel, C., Wiest, R., Cendes, F., Guimaraes, R., Yasuda, C. L., Wang, J.-J., Anderson, T. J., Dalrymple-Alford, J. C., Melzer, T. R., Pitcher, T. L., Schmidt, R., Schwingenschuh, P., Garraux, G., … for the ENIGMA consortium. (2022). Learning interpretable regularized ordinal models from 3D mesh data for neurodegenerative disease staging. In Abdulkadir, Bathula, Dvornek, Habes, Kia, Kumar, & Wolfers (Eds.),. Machine Learning in Clinical Neuroimaging,
13596, .
10.1007/978-3-031-17899-3_12
2021
Basukala, D., Mukundan, R., Lim, A., Hurrell, M. A., Keenan, R. J., Dalrymple-Alford, J. C., Anderson, T. J., Myall, D. J., Melzer, T. R. (2021). Automated segmentation of substantia nigra and red nucleus using quantitative susceptibility mapping images: application to Parkinson’s disease. Computers & Electrical Engineering,
91, .
10.1016/j.compeleceng.2021.107091
Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Langevin, S., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2021). Association of subcortical gray-matter volumes with life-course-persistent antisocial behavior in a population-representative longitudinal birth cohort. Development and Psychopathology,
1–11.
10.1017/S0954579421000377
Elliott, M. L., Caspi, A., Houts, R. M., Ambler, A., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R., Knodt, A., Leung, J. H., Melzer, T. R., Purdy, S. C., Ramrakha, S., Richmond-Rakerd, L. S., Righarts, A., Sugden, K., Thomson, W. M., Thorne, P. R., Williams, B. S., Wilson, G., Hariri, A. R., Poulton, R., Moffitt, T. E. (2021). Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy. Nature Aging,
1, .
10.1038/s43587-021-00044-4
Elliott, M.L., Belsky, D.W., Knodt, A.R., Ireland, D., Melzer, T.R., Poulton, R., Ramrakha, S., Caspi, A., Moffitt, T.E. and Hariri, A.R. (2021). Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort. Molecular Psychiatry,
26, .
10.1038/s41380-019-0626-7
Horne, K., MacAskill, M. R., Myall, D. J., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple‐Alford, J. C. (2021). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. Movement Disorders Clinical Practice,
8, .
10.1002/mdc3.13151
Laansma, M. A., Bright, J. K., Al‐Bachari, S., Anderson, T. J., Ard, T., Assogna, F., Baquero, K. A., Berendse, H. W., Blair, J., Cendes, F., Dalrymple‐Alford, J. C., Bie, R. M. A., Debove, I., Dirkx, M. F., Druzgal, J., Emsley, H. C. A., Garraux, G., Guimarães, R. P., Gutman, B. A., Helmich, R. C., Klein, J. C., Mackay, C. E., McMillan, C. T., Melzer, T. R., Parkes, L. M., Piras, F., Pitcher, T. L., Poston, K. L., Rango, M., Ribeiro, L. F., Rocha, C. S., Rummel, C., Santos, L. S. R., Schmidt, R., Schwingenschuh, P., Spalletta, G., Squarcina, L., Heuvel, O. A., Vriend, C., Wang, J., Weintraub, D., Wiest, R., Yasuda, C. L., Jahanshad, N., Thompson, P. M., Werf, Y. D., The ENIGMA‐Parkinson’s Study. (2021). International multicenter analysis of brain structure across clinical stages of Parkinson’s disease. Movement Disorders ,
36, .
10.1002/mds.28706
Morgan, C. A., Melzer, T. R., Roberts, R. P., Wiebels, K., Mutsaerts, H. J. M. M., Spriggs, M. J., Dalrymple-Alford, J. C., Anderson, T. J., Cutfield, N. J., Deib, G., Pfeuffer, J., Addis, D. R., Kirk, I. J., Tippett, L. J. (2021). Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia. Scientific Reports,
11(1), .
10.1038/s41598-021-02313-z
Murray, S. J., Russell, K. N., Melzer, T. R., Gray, S. J., Heap, S. J., Palmer, D. N., Mitchell, N. L. (2021). Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease. Experimental Eye Research,
207, .
10.1016/j.exer.2021.108600
Richmond-Rakerd, L. S., Caspi, A., Ambler, A., d’Arbeloff, T., de Bruine, M., Elliott, M., Harrington, H., Hogan, S., Houts, R. M., Ireland, D., Keenan, R., Knodt, A. R., Melzer, T. R., Park, S., Poulton, R., Ramrakha, S., Rasmussen, L. J. H., Sack, E., Schmidt, A. T., … Moffitt, T. E. (2021). Childhood self-control forecasts the pace of midlife aging and preparedness for old age. Proceedings of the National Academy of Sciences,
118, .
10.1073/pnas.2010211118
Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., Moffitt, T. E., Caspi, A., Hariri, A. R. (2021). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry,
178.
10.1176/appi.ajp.2020.19090934
d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., Ramrakha, S., Poulton, R., Caspi, A., Moffitt, T. E., Hariri, A. R. (2021). Midlife cardiovascular fitness is reflected in the brain’s white matter. Frontiers in Aging Neuroscience,
13, .
10.3389/fnagi.2021.652575
2020
Almuqbel, M., Melzer, T. R., Oram, B. J., Keenan, R. J. (2020). Compressed sensing in metal hip imaging: our experience. MAGNETOM Flash,
77, .
Borlase, N., Melzer, T. R., Eggleston, M. J., Darling, K. A., Rucklidge, J. J. (2020). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: results of a randomised placebo-controlled trial. Nutritional Neuroscience ,
23, .
10.1080/1028415X.2019.1574329
Borlase, N., Myall, D., Melzer, T., Livingston, L., Watts, R., Keenan, R., MacAskill, M., Anderson, T., Dalrymple-Alford, J. (2020). Microstructural integrity of the major nuclei of the thalamus in Parkinson’s disease. bioRxiv, .
10.1101/2020.05.21.109660
Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Hariri, A. R., Viding, E. (2020). Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort. The Lancet Psychiatry,
S22150366203000.
10.1016/S2215-0366(20)30002-X
Darlow, B. A., Woodward, L. J., Levin, K. J., Melzer, T., Horwood, L. J. (2020). Perinatal and childhood predictors of general cognitive outcome at 28 years in a very‐low‐birthweight national cohort. Developmental Medicine & Child Neurology,
62(12), .
10.1111/dmcn.14649
Grasby, K. L. & Jahanshad, N. et al. (2020). The genetic architecture of the human cerebral cortex. Science,
367(6484), .
10.1126/science.aay6690
Melzer, T.R., Keenan, R.J., Leeper, G.J., Kingston-Smith, S., Felton, S.A., Green, S.K., Henderson, K.J., Palmer, N.J., Shoorangiz, R., Almuqbel, M.M., Myall, D.J. (2020). Test-retest reliability and sample size estimates after MRI scanner relocation. Neuroimage 211, .
10.1016/j.neuroimage.2020.116608
Myall, D.J., Horne, K., MacAskill, M.R., Livingston, L., Pitcher, T.L., Melzer, T.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2020). Cognitive tests that identify high risk of conversion to dementia in Parkinson's disease. bioRxiv, .
10.1101/2020.05.31.126870
Romer, A.L., Elliott, M.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E., Caspi, A., Hariri, A.R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry.
10.1176/appi.ajp.2020.19090934
Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: a mixed methods study. Disability and Rehabilitation,
42, 1942-1953.
10.1080/09638288.2018.1542461
Theys, C., Kovacs, S., Peeters, R., Melzer, T. R., van Wieringen, A., De Nil, L. F. (2020). Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers. PLOS One,
15(1), .
10.1371/journal.pone.0228452
Wheelock, M. D., Lean, R. E., Bora, S., Melzer, T. R., Eggebrecht, A. T., Smyser, C. D., Woodward, L. J. (2020). Functional connectivity network disruption underlies domain-specific attention impairments in attention for children born very preterm. Cerebral Cortex.
10.1093/cercor/bhaa303
d’Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T.J., Caspi, A., Moffitt, T. E., Hariri, A. R. (2020). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Communications,
1(1), .
10.1093/braincomms/fcz041
2019
Douglas, K. M., Groves, S., Porter, R. J., Jordan, J., Wilson, L., Melzer, T. R., Wise, R. G., Bisson J. I., Bell, C. J. (2019). Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: a preliminary functional magnetic resonance imaging study. Australian & New Zealand Journal of Psychiatry,
53, .
10.1177/0004867419851860
Ella, A., Barrière, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers,
9, .
10.1093/af/vfz024
Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage,
189, .
0.1016/j.neuroimage.2019.01.068
Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K., Young, B., Pascoe, M., Almuqbel, M. A., Wang, J., Marsh, S., Miller, D. H., Dalrymple-Alford, J. C., Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s disease. Frontiers in Neurology,
10, .
10.3389/fneur.2019.00391
Pascoe, M.J., Melzer, T.R., Horwood, L.J., Woodward, L.J., Darlow, B.A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical,
22, .
10.1016/j.nicl.2019.101780
Romer, A.L., Knodt, A.R., Sison, M.L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T.R., Moffitt, T.E. and Caspi, A. (2019). Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort. Molecular Psychiatry, .
10.1038/s41380-019-0621-z
2018
Almuqbel, M. M, Leeper, G. J., Petelo, J. F., Page, T. J., Melzer, T. R. (2018). MRI artefact in the rectum caused by ingested orthodontic brackets. Radiography,
24, .
10.1016/j.radi.2017.10.002
Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R., Melzer, T. R. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology,
91:20170593, .
10.1259/bjr.20170593
Castellazzi, G., Debernard, L., Melzer, T. R., Dalrymple-Alford, J. C., D’Angelo, E., Miller, D. H., Wheeler-Kingshott, C. A., Mason, D. F. (2018). Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis. Frontiers in Neurology,
9, .
10.3389/fneur.2018.00690
Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., ..., Melzer, Tracy R., ..., Pitcher, Toni L., ..., Anderson, Tim J., ..., Dalrymple-Alford, John C., ..., on behalf of the Enhancing NeuroImaging Genetics through Meta-Analysis Consortium - Genetics working group (2018). The genetic architecture of the human cerebral cortex. BioRxiv, .
10.1101/399402
Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., Johnston, L.C., Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders,
225, .
10.1016/j.jad.2017.07.049
Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., Gray, S. J., Hughes, S. M., Palmer, D. N. (2018). Longitudinal in vivo monitoring of the CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy,
26, .
10.1016/j.ymthe.2018.07.015
Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., Barrell, G. K., Palmer, D.N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain and Behavior,
8, .
10.1002/brb3.1096
Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Hooper, G. J., Anderson, T. J. (2018). Untangling chronic pain and post-concussion symptoms: the significance of depression. Brain Injury,
32, .
10.1080/02699052.2018.1432894
2017
Lean, R. E., Melzer, T. R., Bora, S., Watts, R., Woodward, L. J. (2017). Attention and regional gray matter development in very preterm children at age 12 years. Journal of the International Neuropsychological Society,
23, .
10.1017/S1355617717000388
2016
Almuqbel, M., Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Wood, K., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting. Parkinsonism & Related Disorders,
22, .
10.1016/j.parkreldis.2015.11.008
Wood, K., Myall, D.J., Livingston, L., Melzer, T.R., Pitcher, T.L., MacAskill, M.R., Geurtsen, G.J., Anderson, T.J., Dalrymple-Alford, J.C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson’s disease: Four year longitudinal study. npj Parkinson's Disease,
2, .
10.1038/npjparkd.2015.27
2015
Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead. BMC Pediatrics,
15, .
10.1186/s12887-015-0413-9
Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging.
10.1016/j.pscychresns.2015.10.00
Innes, CRH, Kelly, PT, Hlavac, M, Melzer, TR, Jones, RD (2015). Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep,
38, .
10.5665/sleep.4658
Melzer, T.R., Myall, D.J., MacAskill, M.R., Pitcher, T.L., Livingston, L., Watts, R., Keenan, R.J., Dalrymple-Alford, J.C., Anderson, T.J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLOS ONE,
10, .
10.1371/journal.pone.0143923
2014
Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A., Dalrymple-Alford, J. C., Miller, D. H. , Mason, D.F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, .
10.1136/jnnp-2013-305612
Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C. , Anderson, T.J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study. Journal of Cerebral Blood Flow & Metabolism,
34, .
10.1038/jcbfm.2014.40
2013
Macrae, P., Jones, R., Myall, D., Melzer, T. , Huckabee, M. (2013). Cross-Sectional Area of the Anterior Belly of the Digastric Muscle: Comparison of MRI and Ultrasound Measures. Dysphagia,
28, .
10.1007/s00455-012-9443-8
Melzer, T. (2013). The evolution of diffusion tensor imaging in Parkinson’s disease research. Movement Disorders,
28, .
10.1002/mds.25566
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology,
80, .
10.1212/WNL.0b013e3182929f62
2012
Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry,
83(2), .
10.1186/2047-9158-1-17
Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., Watts, R., Dalrymple-Alford, J. C., Anderson, T. J. (2012). Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study. Translational Neurodegeneration,
1(1), .
10.1186/2047-9158-1-17
2011
Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R., Watts, R., Anderson, T. J. (2011). Characterizing mild cognitive impairment in Parkinson’s disease. Movement Disorders,
26(4), .
10.1002/mds.23592
Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., Jones, R.D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders. Quarterly Journal of Experimental Psychology,
64, .
Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., Shankaranarayanan, A., Alsop, D. C., Dalrymple-Alford, J. C., Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease. Brain,
134(3), .
10.1093/brain/awq377
2010
Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., Kirwan, J., Keenan, R., Wells, S., Porter, R. J., Watts, R., Anderson, T.J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson’s disease. Neurology,
75, .
10.1212/WNL.0b013e3181fc29c9
2008
Butler, A., Anderson, N., Tipples, R., Cook, N., Watts, R., Meyer, J., Bell, A., Melzer, T., Butler, P. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment,
591, .
10.1016/j.nima.2008.03.039
Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., Butler, P.H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Science in Medicine,
31(4), .
Abstracts and Short papers
2022
Zhao, Y., van Heese, E., Laansma, M. A., Al‐Bachari, S., Anderson, T., Assogna, F., ..., Dalrymple-Alford, J., ..., Melzer, T., ..., Pitcher, T., ..., Gutman, B. A. (2022). TV‐L1 Ordinal Logistic Regression Reveals New Morphometric Patterns Related to Parkinsonian Symptom Severity: An ENIGMA‐PD study. Alzheimer's & Dementia,
18, .
10.1002/alz.067037
2020
Horne, K.-L., MacAskill, M. R., Myall, D., Livingston, L., Grenfell, S., Pascoe, M. J., Young, B., Shoorangiz, R., Melzer, T. R., Pitcher, T. L., Anderson, T. J., Dalrymple-Alford, J. C. (2020). Neuropsychiatric symptoms are associated with dementia in Parkinson’s disease but not predictive of it. MedRxiv, 2020, 09,
01, .
https://doi.org/10.1101/2020.09.01.20186312
2019
Basukala, D., Mukundan, R., Melzer, T., Lim, A. (2019). Automated segmentation of substantia nigra and red nucleus in quantitative susceptibility mapping images. In 2019 20th International Conference on Parallel and Distributed Computing,
Applications an.
d'Arbeloff, T., Elliott, M., Knodt, A., Melzer, T., Keenan, R., Ireland, D., … & Hariri, A. (2019). White matter lesions are common in midlife and associated with cognitive decline. Biological Psychiatry, 85(10),
S213.
10.1016/j.biopsych.2019.03.539
2018
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra using weighted thresholding method, In 2018 International Conference on Image and Vision Computing New Zealand (IVCNZ) (pp. 1-6).
Basukala, D., Mukundan, R., Melzer, T., Keenan, R. (2018). Segmentation of substantia nigra for the automated characterization of Parkinson’s disease. In 2018 IEEE International Conference on Image Processing,
Applications an.
2016
Horne, K, Myall, DJ, Livingston, L, Grenfell, SF, Melzer, TR, Pitcher, TL, MacAskill, MR, Anderson, TJ, Dalrymple-Alford, JC (2016). Risk of dementia in Parkinson’s disease: Towards optimal short cognitive testing. Proceedings of the 34th International Winter Conference on Brain Research, .
Melzer, TR, Keenan, RJ, Myall, DJ, Kaur, G, Livingston, L, Horne, K, Marsh, S, MacAskill, MR, Dalrymple-Alford, JC, Anderson, TJ (2016). Amyloid imaging and cognition in Parkinson’s disease: Interim report. Proceedings of the 34th International Winter Conference on Brain Research, .
2015
Almuqbel, M, Melzer, TR, Myall, DJ, MacAskill, MR, Livingston, L, Pitcher, TL, Dalrymple-Alford, JC, Anderson, TJ (2015). Longitudinal magnetic resonance spectroscopy in Parkinson’s disease. Proceedings of the 21st Annual Meeting of the Organization for Human Brain Mapping.
Melzer, TR, Myall, DJ, MacAskill, MR, Livingston, L, Pitcher, TL, Watts, R, Keenan, RJ, Dalrymple-Alford, JC, Anderson, TJ (2015). White matter lesions contribute to future dementia in Parkinson’s disease. Proceedings of the 21st Annual Meeting of the Organization for Human Brain Mapping.
2014
Almuqbel, M., Melzer, T., Myall, D., MacAskill, M., Livingston, L., Wood, K., Pitcher, T., Dalrymple-Alford, J. , Anderson, T. (2014). Cognitive status in Parkinsons disease characterised by magnetic resonance spectroscopy. Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,
32, .
Melzer, T., Myall, D., Livingston L., , Wood, K., Pitcher, T., Keenan, R., MacAskill, M., Dalrymple-Alford, J. , Anderson, T. (2014). White matter lesions - a factor in developing dementia in patients with Parkinsons disease. Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,
32, .
Myall, D., Wood, K., Livingston, L., Pitcher, T., Melzer, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Individualised medicine: Predicting dementia in Parkinsons disease. Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,
32, .
Wood, K., Myall, D., Livingston, L., Melzer, T., Pitcher, T., MacAskill, M., Anderson, T. , Dalrymple-Alford, J. (2014). Comparing mild cognitive impairment criteria in Parkinsons disease: influence on dementia onset. Proceedings of the International Australasian Winter Conference on Brain Research (AWCBR), Queenstown, New Zealand,
32, .
2013
Dalrymple-Alford, J. C., Livingston, L., Melzer, T. R., Wood, K., Goh, T. J., Pitcher, T. L., Graham, C. F., Keenan, R. J., MacAskill, M. R. , Anderson, T.J. (2013). Current perspectives on Parkinsons disease: Cognition to the fore. Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown, Volume 31,
Abstract 29.
Dalrymple-Alford, J., McCurrie, C., Anderson, T., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R. , Melzer, T. (2013). Domain specific cognitive dysfunction in Parkinson’s Disease and associated pattern of grey matter atrophy. Proceedings of the Movement Disorders Society 17th International Congress - Sydney,
Abstract 572..
Debernard, L., Alla, S., Melzer, T., Van Stockum, S., Graham, C., Dalrymple-Alford, J., Miller, DH, Mason, D (2013). Cortical perfusion is associated with cognitive function in relapsing remitting multiple sclerosis patients (Abstract). Multiple Sclerosis,
19(S11), .
10.1177/1352458513502429
Grenfell, S., Melzer, T. R., Young, B., Wang, A, Livingston, L., Keenan, R. J., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Reduced default mode network connectivity and autobiographical memory in mild cognitive impairment. Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,
Volume 31, .
Melzer, T. R., Watts, R., MacAskill, M., Pitcher, T., Livingston, L., Keenan, R., Dalrymple-Alford, J. , Anderson, T. (2013). Serial DTI and cognitive decline in Parkinsons disease. Proceedings of the Movement Disorders Society 17th International Congress, Sydney, Movement Disorders,
28 Supplement 1, .
Wood, K., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., Anderson, T. J. , Dalrymple-Alford, J.C. (2013). Criteria for Parkinson’s disease with mild cognitive impairment associated with increased progression to dementia. Proceedings of the 31st Australasian Winter Conference on Brain Research 2013, Queenstown,
Volume 31, .
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